B ACKGROUND: Propofol is an intravenous anesthetic used worldwide as an anesthesia induction and maintenance agent. Propofol also used as sedation agent in Intensive Care Unit (ICU). Despite it’s usual anesthesia properties, propofol has an unique pharmacologic characteristic, especially as antioxidant and stress response reduction. These advantages suggested propofol has positive effects when ...

Vedolizumab (VDZ) is a selective antibody against α4β7-integrin, which targets leukocyte trafficking in the gastrointestinal tract. The GEMINI studies are Phase 3, randomized, placebo-controlled trials to assess the efficacy of VDZ in induction and maintenance of moderately to severely active ulcerative colitis (GEMINI 1) and Crohn's disease (GEMINI 2). Included in these studies are patients wh...

This paper presents JILDT (Jason Induction of Logical Decision Trees), a library that defines two learning agent classes for Jason, the well known java-based implementation of AgentSpeak(L). Agents defined as instances of JILDT can learn about their reasons to adopt intentions performing first-order induction of decision trees. A set of plans and actions are defined in the library for collectin...

Any attempt to include learning competences in agent technologies, involves the problem of integrating such competences in the rationality of the agents. This work discusses the design of learning intentional agents in a multiagent system (MAS). Learning intentionally means that these agents learn to adopt their intentions under practical reasoning considerations, specified in terms of Beliefs,...

We examine the issues that arise in extending an estimatedregression planner to find plans for multiagent teams, cooperating agents that take orders but do no planning themselves. An estimated-regression system is a classical planner that searches situation space, using as a heuristic numbers derived from a backward search through a simplified space, summarized in the regression-match graph. Ex...

Light induces retinal synthesis via photoactivation of a small amount of Chlamydomonas rhodopsin pigment (Foster et al., Proc. Natl. Acad. Sci. USA 85, 6379-6383). A reducing agent [dithiothreitol (DDT) or mercaptoacetic acid (MAA)] also induces retinal synthesis in the dark via a rhodopsin with a chromophore. If the opsin is saturated with retinal and is bleached with light in the presence of ...

Reinforcement-based agents have difficulties in transferring their acquired knowledge into new different environments due to the common identities-based percept representation and the lack of appropriate generalization capabilities. In this paper, the problem of knowledge transferability is addressed by proposing an agent dotted with decision tree induction and constructive induction capabiliti...

The authors describe etomidate, a new intravenous nonbarbiturate hypnotic for induction of anesthesia, through a series of three separate studies undertaken at their medical facility. The results of their studies coincide with the experience of other researchers, showing etomidate to be a useful agent for induction because of its rapid onset, short duration of action, and minimal cardiovascular...

Arsenic has been used as an effective chemotherapy agent for some human cancers, such as acute promyelocytic leukemia. In this study, we found that arsenic induces activation of c-Jun NH2-terminal kinases (JNKs) at a similar dose range for induction of apoptosis in JB6 cells. In addition, we found that arsenic did not induce p53-dependent transactivation. Similarly, there was no difference in a...

Arsenic has been used as an effective chemotherapy agent for some human cancers, such as acute promyelocytic leukemia. In this study, we found that arsenic induces activation of c-Jun NH2-terminal kinases (JNKs) at a similar dose range for induction of apoptosis in JB6 cells. In addition, we found that arsenic did not induce p53-dependent transactivation. Similarly, there was no difference in a...