Chloroacetaldehyde (CAA) is a chlorination by-product in finished drinking water and a toxic metabolite of a wide variety of industrial chemicals (e.g. vinyl chloride) and chemotherapeutic agents (e.g. cyclophosphamide and ifosfamide). In this research, the cytotoxic mechanisms of CAA in freshly isolated rat hepatocytes were investigated.CAA cytotoxicity was associated with reactive oxygen spec...

Background: Aluminum (Al) exposure is among the environmental risk factors that may involve in the pathogenesis of neurodegenerative diseases. Oxidative stress has a critical role in the Al-induced toxicity. Saffron is a plant with potent radical scavenging and anti-oxidative properties. This investigation was designed to evaluate the possible protective effects of saffron extract (SE) on alumi...

Selenium (Se) at high concentrations can cause toxic effects in plants, whereas at low concentrations it enhances resistance to certain abiotic stresses. The possible mechanisms of the Se-enhanced tolerance of plants to salinity stress remain elusive. In this work, effect of Se supplementation at 0, 0.1, 1 and 10 mg l-1 sodium selenate was studied in Lallemantia iberica plants subjected to salt...

objective(s): stress induces many homeostatic aberrations which are followed by lifelong allostatic responses. epilepsy is developed or influenced by different environmental factors, i.e. prenatal stress which makes many contradictory developmental changes in seizure threshold and intensity. we investigated the potential seizure response of the rat offspring to prenatal stress; the stress which...

abstract background and objective: alzheimer’s disease (ad) is a weakening neurodegenerative disorder typified by increased b-amyloid (ab) deposition and neuronal dysfunction causing to impaired learning and memory. among proposed risk factors, induced oxidative stress is a main cause for incidence of the disease. the aim of this study was to determine the effects of the rosmarinic acid on lear...

Introduction: Different mechanisms are involved in stress induced analgesia (SIA) and hyperalgesia (SIH). Repeated stress induces development of tolerance to SIA. The role of HPA axis and Gs signaling pathway in these effects are investigated in the current study. Methods: Forced swim stress (5 min/day) in water (20±1 ºC) was employed to adult male Wistar rats (200-250 g). The nociceptive t...

Assessing the tolerance of medicinal plants is important for planting them in drought areas. Arginine is a growth regulator and its role in plants’ tolerance to environmental stresses such as drought has been investigated. To evaluate the protective effects of arginine against osmotic stress induced by polyethylene glycol in ajwain (Trachyspermum ammi) seedlings, an experiment was conducted as ...

The target of interventions to reduce cardiovascular events has focused on total (CHOL) and low-density (LDLC) cholesterol levels. Data from the Framingham Heart Study would suggest that 50% of individuals with so-called “normal” LDLC levels (100 mg/dl or 2.6 mmol/L) would have atherosclerosis by age 50 [1]. In the Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE-IT), aggress...

For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stress-induced analgesia can vary greatly and that this sensitivity is coupled to many different phenotypes including the degree of opioid s...

We demonstrate for the first time a new mechanical annealing method that can significantly improve the structural quality of self-assembled nanoparticle arrays by eliminating defects at room temperature. Using in situ high-pressure small-angle X-ray scattering, we show that deformation of nanoparticle assembly in the presence of gigapascal level stress rebalances interparticle forces within nan...