The analysis of a problem state of chronic hepatitis C in children was conducted. Data on primary incidence of chronic hepatitis C at the children's population as on the territory of the Russian Federation, and abroad are submitted. Problems of diagnosis of a HCV infection are studied. The survey analysis of risk of contamination is carried out, possible ways of transfer are highlighted, featur...

Background: Hepatitis C is a global health problem. The exact mechanisms by which hepatitis C virus (HCV) can evade the host immune system have become controversial. Whether HCV polyproteins modulate IFN signalling pathways or HCV proteins are responsible for such a property is the subject of interest. Therefore, an efficient baculovirus delivery system was developed to introduce the whole geno...

Hepatitis A virus (HAV) infection occurs worldwide and is an important cause of acute viral hepatitis in the US. In this review, I cover the epidemiology, course of infection, clinical manifestations, serological responses, and prevention of this infection. Although most patients completely recover from this disease, elderly patients have a substantial mortality risk. Recently licensed vaccines...

This retrospective study compares the clinical features, laboratory profile and complications of anti HAV IgM positive acute viral hepatitis A in 138 children between 1-15 year (1-5 year: n=31; 5-10 year: n=85; and 10-15 year: n=22). We found that older children presented with HAV (hepatitis A virus) infection with more atypical manifestations (ascites and splenomegaly) and complications.

While several predictors of an early and sustained response can be identified in the treatment of chronic hepatitis B, no consistently demonstrable predictors of response exist for chronic hepatitis C. As such, guidelines for the treatment of chronic hepatitis C are more complex than those for hepatitis B. The treatment options for chronic hepatitis B and C are outlined and there is speculation...

there are few reports concerning interferon induced myocardial dysfunction. a known case of multiple myeloma who was receiving interferon alpha (ifa) for 14 months was brought to the emergency room in frank: pulmonary edema. after treatment of heart failure and discontinuation of interferon alpha, he remained asymptomatic thereafter. another case of chronic active hepatitis on ifa complained of...

abstract mutations have been described in all of the four open reading frames of the hepatitis b virus (hbv), however, from a clinical perspective the surface escape mutant is the most troublesome. hepatitis b surface antigen (hbsag) variants may impair diagnosis, or allow the virus to escape vaccine-induced immunity or passive immunoglobulin therapy. hbv mutants with amino acid substitutions, ...

Hepatitis E virus (HEV) was discovered during the Soviet occupation of Afghanistan in the 1980s, after an outbreak of unexplained hepatitis at a military camp. A pooled faecal extract from affected soldiers was ingested by a member of the research team. He became sick, and the new virus (named HEV), was detected in his stool by electron microscopy. Subsequently, endemic HEV has been identified ...

During the past ten years, several new hepatitis E viruses (HEVs) have been identified in various animal species. In parallel, the number of reports of autochthonous hepatitis E in Western countries has increased as well, raising the question of what role these possible animal reservoirs play in human infections. The aim of this review is to present the recent discoveries of animal HEVs and thei...

D-Galactosamine is one among the most experimentally used drug to study hepatotoxic effects in experimental animals. The model system of liver damage produced by D-galactosamine rats recognized be much like viral hepatitis humans from both morphological and functional points view. It also causes oxidative stress rats. Ajaswagandhadhi Lehyam has ingredients that reduce stress. This deals antioxi...