Ca release from cardiac sarcoplasmic reticulum (SR) via ryanodine receptors (RyRs) is regulated by dyadic cleft [Ca ] and intra-SR free [Ca ] ([Ca ]SR). Robust SR Ca 2 release termination is important for stable excitation–contraction coupling, and partial [Ca ]SR depletion may contribute to release termination. Here, we investigated the regulation of SR Ca release termination of spontaneous lo...

Global analyses of splicing of precursor messenger RNAs (pre-mRNAs) have revealed that alternative splicing (AS) is highly pervasive in plants. Despite the widespread occurrence of AS in plants, the mechanisms that control splicing and the roles of splice variants generated from a gene are poorly understood. Studies on plant serine/arginine-rich (SR) proteins, a family of highly conserved prote...

This is one of three Issue Briefing Notes produced by a partnership of six sustainable development-oriented non-governmental organizations, including three international organizations and three organizations based in developing countries. The Issue Briefing Notes present a general overview of three issues that deserve particular attention in discussions on the possible development by the Intern...

It has been deemed important to normalize flow-mediated dilation (FMD), a marker of endothelial function, for between-subject differences in the eliciting shear rate (SR) stimulus. Conventionally, FMD is divided by the area under the curve of the SR stimulus. In the context of a cross-sectional comparison across different age cohorts, we examined whether this ratio approach adhered to establish...

Objective- In the present study the role of essential oil of Salvia rhtidia (SR), in ameliorating renal ischemia reperfusion (IR) injuries is evaluated. Design- Experimental in vivo study. Animals- 48 male healthy Wistar rats between 250-300 grams. Procedures- The animals were randomly divided into eight groups of six rats. In ischemic groups (groups A-D), under general anesthesia b...

AIMS This study evaluates a simple echocardiographic rhythm independent expression of left atrial (LA) function, 'the left atrial function index' (LAFI). BACKGROUND Quantitation of LA function is challenging and often established parameters including peak A are limited to sinus rhythm (SR). We hypothesized that atrial function could be characterized independent of rhythm by combining analogue...

SR/CR (spontaneous regression/complete resistance) mice resist multiple types of cancer cells injected at numbers that are lethal to wild type (WT) mice. When the anti-tumor response was examined, leukocytes of the innate immune system, including neutrophils (PMN), macrophages and NK cells, infiltrated the tumor site for a multipronged killing response. Each cell type had independent killing ac...

A mathematical model of the cardiac ventricular action potential is presented. In our previous work, the membrane Na+ current and K+ currents were formulated. The present article focuses on processes that regulate intracellular Ca2+ and depend on its concentration. The model presented here for the mammalian ventricular action potential is based mostly on the guinea pig ventricular cell. However...

New calcite Sr/Sr data for 47 limestones from the metamorphosed and deformed Neoproterozoic–Cambrian Dalradian Supergroup of Scotland and Ireland are used to identify secular trends in seawater Sr/Sr through the Dalradian succession and to constrain its depositional age. Dalradian limestones commonly have Sr .1000 ppm, indicating primary aragonite and marine diagenesis. Low Mn, Mn/Sr ,0.6, O an...

We have developed a detailed mathematical model for Ca2+ handling and ionic currents in the rabbit ventricular myocyte. The objective was to develop a model that: 1), accurately reflects Ca-dependent Ca release; 2), uses realistic parameters, particularly those that concern Ca transport from the cytosol; 3), comes to steady state; 4), simulates basic excitation-contraction coupling phenomena; a...