The Wave proteins activate the Arp2/3 complex at the leading edge of migrating cells. The resulting actin polymerization powers the projection of the plasma membrane in lamellipodia and membrane ruffles. The Wave proteins are always found associated with partner proteins. The canonical Wave complex is a stable complex containing five subunits. Even though it is well admitted that this complex p...

The literature on categorial type logic includes proposals for semantically inactive additives, quantifiers, and modalities Morrill (1994[17]), Hepple (1990[2]), Moortgat (1997[9]), but to our knowledge there has been no proposal for semantically inactive multiplicatives. In this paper we formulate such a proposal (thus filling a gap in the typology of categorial connectives) in the context of ...

A striking difference between male and female nuclei was recognized early on by the presence of a condensed chromatin body only in female cells. Mary Lyon proposed that X inactivation or silencing of one X chromosome at random in females caused this structural difference. Subsequent studies have shown that the inactive X chromosome (Xi) does indeed have a very distinctive structure compared to ...

X-inactivation is the unusual mode of gene regulation by which most genes on one of the two X chromosomes in female mammalian cells are transcriptionally silenced. The underlying mechanism for this widespread transcriptional repression is unknown. This thesis investigates two key aspects of the X-inactivation process. The first aspect is the correlation between chromatin structure and gene expr...

Hepatic lipase activity is detectable in liver but also in adrenal glands, ovaries, and plasma. The subunit size of hepatic lipase in liver, adrenal glands, and nonheparin plasma was compared. Hepatic lipase in liver and adrenal glands appeared as a 55 kDa band. In liver, a faint band of lower size was also detected. In nonheparin plasma, hepatic lipase appeared as a doublet of 57 kDa and 59 kD...

PURPOSE To assess the self-esteem of Graves' ophthalmopathy patients in the inactive phase. METHODS Thirty euthyroid patients were evaluated in the inactive phase of disease with age ranging from 26 to 65 years, average of 43 +/- 11,0 years, called study group and 39 individuals without Graves' ophthalmopathy with age ranging from 18 to 67 years, average of 41 +/- 13,4 years, selected from th...

The initiation of DNA replication is tightly regulated in order to ensure that the genome duplicates only once per cell cycle. In vertebrate cells, the unstable regulatory protein Geminin prevents a second round of DNA replication by inhibiting the essential replication factor Cdt1. Cdt1 recruits mini-chromosome maintenance complex (MCM2-7), the replication helicase, into the pre-replication co...

THE concept of an association between congenital syphilitic interstitial keratitis and the development of late glaucoma is not new. Hutchinson (1863) reported the case of a man aged 24 with congenital syphilis who had suffered bilateral interstitial keratitis at the age of 6; both eyes had deeply cupped and atrophic optic discs and iridectomy failed to control the glaucoma. Hutchinson believed ...