Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis and is controlled, at least in part, through AMP-activated protein kinase and p38-dependent pathways. There is evidence demonstrating that activation of these kinases and induction of PGC-1α in skeletal muscle are regulated by catecholamines. The purpose of the present study wa...

BACKGROUND Maximal oxygen uptake (VO(2max)) predicts mortality and is associated with endurance performance. Trained subjects have a high VO(2max) due to a high cardiac output and high metabolic capacity of skeletal muscles. Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a nuclear receptor coactivator, promotes mitochondrial biogenesis, a fiber-type switch to oxidative fi...

The color of the gingiva has a tremendous impact on the esthetics of the smile. Clinically gingival melanin hyper pigmentation is presented as ‘black gum’ which is a common esthetic problem especially for those who have gummy smile. Several attempts have been made for removal of gingival pigmentation by different techniques. Each technique had its own supremacy in efficiency and also draw back....

Hindu medicine correctly judged by him is a composite system. It consists of a Dravidian system on which was superimposed an Aryan system on which in its turn was superimposed a Buddhist system. The Dravidian system centres round Dhanvantari who does not figure in the vedic pantheon of the Aryan immigrants. He is one of the 14 jewels churned out of the milky ocean at the beginning of time when ...

O n March 31, 2015, the Supreme Court issued its much anticipated (some would say dreaded) decision in Armstrong v. Exceptional Child Center, Inc. 1 A 5-4 majority (Justice Scalia, joined by Chief Justice Roberts and Justices Alito, Thomas and Breyer) concluded that health care providers have no right to sue States under the Supremacy Clause for prospective relief against Medicaid rate cuts all...

Many prominent jurists and scholars, including those with outlooks as diverse as Chief Justice John Roberts and Cass Sunstein, have recently advocated a “minimalist” approach to opinion writing at the Supreme Court. They assert that the Court should issue narrow, fact-bound decisions that do not resolve much beyond the case before it. I argue that minimalism, as employed by the current Supreme ...

An Unified Power Flow Controller (UPFC) is a typical Flexible AC Transmission System (FACTS) device playing a vital role as a stability aid for large transient disturbances in an interconnected power system.This paper deals with the design of Feedback Linearising Controller (FBLC) for UPFC.The disturbances are created in the SMIB system and the results are simulated.The results proved the supre...

Birds arose from their dinosaur ancestors and took to the skies over 100 million years ago. Since that time, birds have become abundant at high elevation, they have acquired the ability to migrate over the world’s highest mountains, and they have even found reason to soar over 11,000 m above sea level (18). These anecdotal observations alone may convince some of an avian supremacy at elevation....

Underexpression of the transcriptional coactivator PGC-1α is causally linked to certain neurodegenerative disorders, including Huntington's Disease (HD). HD pathoprogression is also associated with aberrant NMDAR activity, in particular an imbalance between synaptic versus extrasynaptic (NMDAR(EX)) activity. Here we show that PGC-1α controls NMDAR(EX) activity in neurons and that its suppressio...