The first triboelectric-nanogenerator (TENG)-based self-powered implantable drug-delivery system is presented. Pumping flow rates from 5.3 to 40 µL min-1 under different rotating speeds of the TENG are realized. The implantable drug-delivery system can be powered with a TENG device rotated by human hand motion. Ex vivo trans-sclera drug delivery in porcine eyes is demonstrated by utilizing the ...

All of the prospective multicenter trials that support the use of implantable defibrillators have used single chamber pacemakers/implantable cardiovertor defibrillators (ICDs). Despite the significantly increased cost of dual chamber pacemaker/ICD devices and the lack of outcome data, these devices accounted for approximately two-thirds of the ICDs implanted in the United States during the 12 m...

Designing bug-free medical device software is difficult, especially in complex implantable devices used for rhythm management of the cardiac or the neurological system. There is currently no formal methodology or open experimental platform to validate the correct operation of implantable medical device software. We describe our recent work on heart modeling for the validation and verification o...

— We are working towards the speci cation and design of a new system-level architecture serving as the digital control/processing core of ultra-low-power (< 100 μW ) and reliable systems along with a suitable, new compiler. Our primary area of focus is implantable microelectronic devices. While respecting the traditional design constraints of biomedical-implant design for low power consumption ...

Posterior Chamber Phakic Toric Implantable Collamer Lenses have become increasingly used to correct refractive error associated with astigmatism. These devices are claimed to provide high efficacy in terms of refractive correction. This book chapter is an updated review on the safety and effectiveness and potential complications of the toric implantable collamer lens (Toric ICL) published in pe...

There has been a significant increase in the number of patients receiving cardiovascular implantable electronic devices (CIED) over the last two decades. CIED infection represents a serious complication after CIED implantation and is associated with significant morbidity and mortality. Recently, newly advanced technologies have offered attractive and suitable therapeutic alternatives. Notably, ...

The vagus nerve is a major component of the autonomic nervous system and plays a critical role in many body functions including for example, speech, swallowing, heart rate and respiratory control, gastric secretion, and intestinal motility. Vagus nerve stimulation (VNS) refers to any technique that stimulates the vagus nerve, with electrical stimulation being the most important. Implantable dev...

Three-dimensional (3D) bioprinting is a revolutionary technology in building living tissues and organs with precise anatomic control and cellular composition. Despite the great progress in bioprinting research, there has yet to be any clinical translation due to current limitations in building human-scale constructs, which are vascularized and readily implantable. In this article, we review the...

Low-power circuit design techniques have enabled the possibility of integrating signal processing and feature extraction algorithms on-board implantable medical devices, eliminating the need for wireless transfer of data outside the patient. Feature extraction algorithms also serve as valuable tools for modern-day artificial prostheses, made possible by implantable brain-computer-interface syst...

JR.: Indications for and results of implanting cardiac pacemakers, Amer. J. Med., 37:764, 1964. 15 CENTER, S., NATHAN, D., WU, C.Y., AND DUCNE, D.: Two years of clinical experience with the synchronous pacer, I. Thorac. and Cardiovas. Surg., 48:513, 1964. 16 CHARDACK, W.M., GAGE, A.A., FEDERICO, A.J., SCHIMERT, G., AND GREATBATCH, W.: Five years clinical experience with an implantable pacemaker...