Coronary artery disease (CAD) has been shown in previous uncontrolled studies to be a limiting factor to long-term survival in patients undergoing cardiac transplantation and who were taking conventional immunosuppressive agents. To study the development of CAD after cardiac transplantation in patients taking the newer immunosuppressive agent cyclosporine, we prospectively performed yearly coro...

Progressive multifocal leucoencephalopathy (PML) is a rare and often fatal opportunistic infection that has been well reported in patients with rheumatic diseases. The contributions of predisposing factors such as underlying disease and immunosuppressive drug selection are incompletely understood but it would appear that patients with systemic lupus erythematosus may be at highest risk. Nataliz...

The past decade has witnessed the introduction of several new immunosuppressive agents. The availability of these new agents has led to attempts to determine which is the best combination of maintenance immunosuppression for the patients, based on efficacy and reduction of adverse effects. Steroid avoidance, withdrawal and minimization regimens are being assessed. Calcineurin withdrawal or mini...

Severe acute respiratory syndrome coronavirus (SARS-COV-2) presented with pulmonary symptoms and various extra manifestations including dermatological like urticarial, acralvascular lesion erythematous maculopapular rash, vesicular rash. Herpes zoster is a painful rash resulting from reactivation of varicella-zoster (VZ) virus that also causative agent chickenpox. The incidence HZ infection (HZ...

Aspergillus fumigatus causes invasive pulmonary aspergillosis (IPA). This disease is one of the most life-threatening opportunistic infections in immunocompromised patients. The type of immunosuppressive regimen under which IPA occurs has rarely been investigated. In this study, we evaluated various parameters of the innate immune response during the progression of murine IPA induced by the int...

i.-Asparaginase is a chemotherapeutic agent that is also immunosuppressive, inhibiting both the cellular and hu moral responses. This study deals with the effects of the enzyme on lymphocyte surface receptors to the mitogen concanavalin A. We previously reported that short incu bation of lymphocytes with L-asparaginase leads to a de creased binding of the mitogen to their surface. We now re por...

The last several decades have witnessed a substantial decrease in the incidence of acute allograft rejection following kidney transplantation, although commensurate improvements in long-term graft function have not been realized. As a result, the primary focus of new immunosuppressive drug development has expanded to include ease of use and improved side effect profile, including reduced nephro...

Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Immunosuppressive states due to immunological senescence (1) or administration of immunosuppressants (2) occasionally cause Epstein-Barr virus (EBV)-induced B-cell lymphoproliferative disorders (LPDs). While methotrexate (MTX) is an anti-metabolite and anti-foliate agent for the treatment of cancers and autoimmune disorders, ...

Pre-treatment or priming of mesenchymal stem cells (MSC) prior to transplantation can significantly augment the immunosuppressive effect of MSC-based therapies. In this study, we screened a library of 1402 FDA-approved bioactive compounds to prime MSC. We identified tetrandrine as a potential hit that activates the secretion of prostaglandin E2 (PGE2), a potent immunosuppressive agent, by MSC. ...