نتایج جستجو برای: immunogenic response

تعداد نتایج: 983179  

Journal: :Cancer genomics & proteomics 2007
Lionel Apetoh Michel Obeid Antoine Tesniere François Ghiringhelli Gian Maria Fimia Mauro Piacentini Guido Kroemer Laurence Zitvogel

The aim of chemotherapy and radiotherapy is to eliminate tumor cells. While the outcomes of these cytotoxic treatments have previously been assigned to their direct effects on tumor cells, recent findings have shown that the host's immune system also contributes to the success of chemotherapeutic and radiotherapeutic regimens. The finding that some cytotoxic antitumor coumpounds such as anthrac...

2017
Richard Nuccitelli Amanda McDaniel Snjezana Anand John Cha Zachary Mallon Jon Casey Berridge Darrin Uecker

BACKGROUND We have been developing a non-thermal, drug-free tumor therapy called Nano-Pulse Stimulation (NPS) that delivers ultrashort electric pulses to tumor cells which eliminates the tumor and inhibits secondary tumor growth. We hypothesized that the mechanism for inhibiting secondary tumor growth involves stimulating an adaptive immune response via an immunogenic form of apoptosis, commonl...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شیراز - دانشکده دندانپزشکی 1380

چکیده ندارد.

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه صنعتی اصفهان - دانشکده شیمی 1390

abstract venlafaxine, 1–[2–(dimethylamino)–1–(4–methoxyphenyl) ethyl]cyclohexanol hydrochloride is a novel non-tricyclic antidepressant. venlafaxine is a second generation antidepressant drug, has a neuropharmacologic profile distinct from that of existing antidepressants including tricyclic compounds, selective serotonin reuptake inhibitors and monoamine oxidase inhibitors. venlafaxine impart...

Journal: :Oncotarget 2016
Shelly Kalaora Eilon Barnea Efrat Merhavi-Shoham Nouar Qutob Jamie K Teer Nilly Shimony Jacob Schachter Steven A Rosenberg Michal J Besser Arie Admon Yardena Samuels

The antigenicity of cells is demarcated by the peptides bound by their Human Leucocyte Antigen (HLA) molecules. Through this antigen presentation, T cell specificity response is controlled. As a fraction of the expressed mutated peptides is presented on the HLA, these neo-epitopes could be immunogenic. Such neo-antigens have recently been identified through screening for predicted mutated pepti...

Journal: :Journal of immunology 2002
Philippe Halbout Jean-Paul Briand Chantal Bécourt Sylviane Muller Christian Boitard

Immunization against insulin, insulin B chain, or B chain peptide B(9-23) (preproinsulin peptide II(33-47)) prevents diabetes in the nonobese diabetic (NOD) mouse. Whether or not peptide II(33-47) is the only proinsulin determinant recognized by CD4 T cells remains unclear. Using two peptide libraries spanning the entire sequence of preproinsulin I and preproinsulin II, respectively, we identif...

2016
Yujia Wang Ji Bao Xiujuan Wu Qiong Wu Yi Li Yongjie Zhou Li Li Hong Bu

Decellularized xenogeneic whole-liver matrices are plausible biomedical materials for the bioengineering of liver transplantation. A common method to reduce the inflammatory potential of xenogeneic matrices is crosslinking. Nevertheless, a comprehensive analysis of the immunogenic features of cross-linked decellularized tissue is still lacking. We aimed to reduce the immunogenicity of decellula...

2010
David M. Markusic Dirk R. de Waart Jurgen Seppen

BACKGROUND Lentiviral gene transfer can provide long-term expression of therapeutic genes such as erythropoietin. Because overexpression of erythropoietin can be toxic, regulated expression is needed. Doxycycline inducible vectors can regulate expression of therapeutic transgenes efficiently. However, because they express an immunogenic transactivator (rtTA), their utility for gene therapy is l...

2017
Jason W. Lee Natalie A. Parlane D. Neil Wedlock Bernd H. A. Rehm

Many bacterial pathogens naturally form cellular inclusions. Here the immunogenicity of polyhydroxyalkanoate (PHA) inclusions and their use as particulate vaccines delivering a range of host derived antigens was assessed. Our study showed that PHA inclusions of pathogenic Pseudomonas aeruginosa are immunogenic mediating a specific cell-mediated immune response. Protein engineering of the PHA in...

Journal: :Blood 2005
Marie-Ghislaine de Goër de Herve Deniz Durali Tú-Anh Tran Gwénola Maigné Federico Simonetta Philippe Leclerc Jean-François Delfraissy Yassine Taoufik

Agonistic monoclonal antibodies to CD40 (CD40 mAbs) have a puzzling dual therapeutic effect in experimental animal models. CD40 mAbs induce tumor regression by potentiating antitumoral T-cell responses, yet they also have immunosuppressive activity in chronic autoimmune inflammatory processes. CD40 mAbs are thought to act on antigen presentation by dendritic cells (DCs) to T cells. DCs can be d...

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