In many diseases (e.g. autoimmune diseases, cancer), a humoral immune response is thought to be involved; therefore, identifying relevant antigens that trigger the humoral immune response is at the heart of current approaches for discovering biomarkers and designing therapeutic strategies. Although immunoblotting and protein array have been used for antigen profiling in several diseases, with t...

T cells that recognize nonpeptidic antigens, and thereby are identified as nonclassical, represent important yet poorly characterized effectors of the immune response. They are present in large numbers in circulating blood and tissues and are as abundant as T cells recognizing peptide antigens. Nonclassical T cells exert multiple functions including immunoregulation, tumor control, and protecti...

B cell activation and antibody production against foreign antigens is a central step of host defense. This is achieved via highly regulated multi-phase processes that involve a variety of cells of both innate and adaptive arms of the immune system. MHC class II-restricted CD4+ T cells specific for peptide antigens, which acquire professional follicular B cell helper functions, have been long re...

Malaria infection induces the production of serum antibodies to a variety of malaria antigens but the prevalence of antibodies to any particular antigen is typically much less than 100%. It has been assumed that non-responsiveness to defined antigens in malaria immune subjects is due to HLS-mediated restriction of the immune response. In this study we have investigated the role of HLA and non-H...

OBJECTIVE To evaluate the immune response in Peruvian children following measles vaccination. METHODS Fifty-five Peruvian children received Schwarz measles vaccine (about 10(3) plaque forming units) at about 9 months of age. Blood samples were taken before vaccination, then twice after vaccination: one sample at between 1 and 4 weeks after vaccination and the final sample 3 months post vaccin...

Background: Despite several attempts, the etiopathogenesis of anorexia nervosa (AN) is still unknown. However, activation immune response in neuropsychiatric diseases, including AN, increasingly evident. We aimed to explore parameters patients with AN and identify link between presence specific autoantibodies for hypothalamic antigens inflammatory response. The relationship markers duration dis...

Prevention of an immune response against self-antigens derived from apoptotic cells is essential to preclude autoimmune and chronic inflammatory diseases. Here, we describe apoptosis induced externalization of endogenous cytosolic annexin 1 initiating an anti-inflammatory effector mechanism that suppresses the immune response against antigens of apoptotic cells. Cytosolic annexin 1 rapidly tran...