It has been reported that the serum level of vitamin D3 (VitD3) could affect the natural course of chronic hepatitis C (CH-C) and the response to treatment with pegylated interferon (Peg-IFN) and ribavirin. Although several mechanisms for the favorable effects of VitD3 supplementation were reported, the total effect of VitD3 supplementation remains unclear. Previously, we reported that suppleme...

Little is known about the role of CD1d-restricted T cells in antiviral immune responses. Here we show that the lytic replication cycle of the Kaposi sarcoma-associated herpesvirus (KSHV) promotes downregulation of cell-surface CD1d. This is caused by expression of the 2 modulator of immune recognition (MIR) proteins of the virus, each of which promotes the loss of surface CD1d expression follow...

The inflammasome is a multiprotein complex that further regulates cell pyroptosis and inflammation by activating caspase-1. assembly activation of are associated with variety diseases. Accumulative studies have shown key modulator the host’s defense response to viral infection. Indeed, it has been established occurs during At same time, host evolved corresponding mechanisms inhibit unnecessary ...

The tumor suppressor p15Ink4b is frequently inactivated by methylation in acute myeloid leukemia and premalignant myeloid disorders. Dendritic cells (DCs) as potent APCs play critical regulatory roles in antileukemic immune responses. In the present study, we investigated whether p15Ink4b can function as modulator of DC development. The expression of p15Ink4b is induced strongly during differen...

In this paper, the preferred region of design parameters for quasi-normalized equations of single-axis attitude control of rigid spacecraft using pulse-width pulse-frequency modulator (PWPFM) is presented for rest-to-rest maneuvers. Using the quasi-normalized equations for attitude control reduces the system parameters, that is, the moment of inertia, the filter gain, and the maximum torque of ...

introduction hydrops fetalis is a serious condition in fetal period, characterized by the presence of serous fluid accumulation in at least two potential spaces in fetus including pleural effusion, pericardial effusion, and ascites. the incidence of hydrops fetalis is one per 2500-3000 pregnancies. this condition is followed by different diseases. fetal hemolytic anemia and its hypoxemia due to...

Nanoparticle-based delivery systems for cancer immunotherapies aim to improve the safety and efficacy of these treatments through local specialized antigen-presenting cells (APCs). Multifunctional mesoporous silica nanoparticles (MSNs), with their large surface areas, tunable particle pore sizes, spatially controlled functionalization, represent a safe versatile carrier system. In this study, w...