The present study was undertaken to evaluate the anti-depressive activity of a polyherbal formulation (PF) after 28 days administration by using a rat forced swimming test (FST) and tail suspension test (TST). Animals were divided into six groups (n=6/group): group-1: The control rats received injections of 0.5% CMC solution only; group 2: FST+vehicle, groups 3: FST+SER (10 mg/kg, i.p.); group ...

Serotonin is involved in a wide range of physiological and patho-physiological mechanisms. In particular, 5-HT1A receptors are proposed to mediate stress-adaptation. The aim of this research was to investigate in adolescent rats: first, the consequences of perinatal exposure to 5-metoxytryptamine (5MT), a 5-HT1/5-HT2 serotonergic agonist, on behavioural-stress reactivity in elevated plus maze, ...

Transient osteoporosis is a rare condition causing regional pain, immobility and functional compromise. The authors present the case of a pregnant lady with multiple sites of transient osteoporosis, including a stress fracture, successfully treated with intravenous pamidronate and a physical rehabilitation programme. The authors discuss the mechanisms for the syndrome and its overlap with compl...

BACKGROUND In this study, we investigate the effects of valerian root extracts (VE) on physical and psychological stress responses by utilizing a communication box. METHODS Eight-week-old ICR mice received oral administration of VE (100 mg/kg/0.5 ml) or equal volume of distilled water in every day for 3 weeks prior to being subjected to physical or psychological stress for 3 days, which are i...

Introduction During the final 48 hours of life, patients experience increasing weakness and immobility, loss of interest in food and drink, difficulty swallowing, and drowsiness. With an incurable and progressive illness, this phase can usually be anticipated, but sometimes a deterioration can be sudden and distressing. Control of symptoms and family support take priority, and the nature of the...

vitamin b6 is a cofactor of various enzymes influencing numerous neurotransmitters in the brain such as norepinephrin, and serotonin . since these neurotransmitters influence mood , the aim the present work to evaluate the effect of vitamin b6 on depression and obsessive compulsive behavior when coadministred with clomipramine, fluoxetine, or venlafaxine. male mice weighing 25-30 g were used. t...

Tonic immobility reaction and heterophil:lymphocyte ratio were studied in hens laying pink eggs from three brown egg Spanish breeds (Barred Red Vasca, Red Vasca, Red Villafranquina). There was no significant difference among breeds in terms of tonic immobility duration or heterophil:lymphocyte ratio. Tonic immobility duration was significantly shorter in the pink (220 + or - 23 s) than in the n...

In this study we analyzed the effects of melatonin (Mel, 1 mg/kg ip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbect...