OBJECTIVE This is an analysis of the unpublished continuation phase of Study 329, the primary objective of which was to compare the efficacy and safety of paroxetine and imipramine with placebo in the treatment of adolescents with unipolar major depression. The objectives of the continuation phase were to assess safety and relapse rates in the longer term. The objective of this publication, und...

I n the article " Pharmacologic treatment of depression in late life " Alastair Flint gives a thorough and comprehensive review of the treatment of depression. He mentions that to his knowledge, " only 1 trial has compared an SSRI [selective serotonin reuptake inhibitor] (sertra-line) with a secondary amine TCA [tricyclic antidepressant] (nortripty-line), and both drugs were equally well tolera...

Objective: The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans(MS). Materials and Methods: Male Wistar rats were subjected to imipramine and herbal extract ofMS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST). Results: Administr...

Background: Primary nocturnal enuresis is a common disorder that often leads to considerable distress in affected children and their family. In many countries pharmacologic therapy is preferred to non-pharmacologic behavioral and conditional alarm therapy. Imipramine, oxybutynin, and desmopressin have been used for enuresis with various efficacies. The aim of the present study was to compare th...

Escitalopram is a widely used antidepressant and antianxiety agent in clinical setup. This study was aimed at developing validating very sensitive specific bioanalytical method for the estimation of escitalopram rat plasma using liquid chromatography coupled with tandem mass spectrometry as per current United States Food Drug Administration (May 2018) guideline. The spectrometer operated heated...