In the reaction of 5-arylidene-2,4-dioxothiazolidine-3-acetic acid chloride with 1,2,4-triazole, 1,2,4-triazoline-5-one and 1,2,4-triazoline-5-thione, the new corresponding 5-arylidene-2,4-dioxothiazolidine-3-acetic acid amides (5-16) were obtained. Compounds 6, 14 i 15 were investigated in vitro for their antioxidant activity.

The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold have found many applications in recent years. This review is aimed at highlighting the most important aspects about these compounds: synthesis, spectroscopic characterization and antiprotozoan activities. How the chemical nature of N-substituents influences the overall activity / cytotoxicity profile will also be discussed.

Thia-Claisen rearrangements have been carried out using N-benzylpyrrolidine-2-thione and chiral allylic bromides derived from D-mannitol. Introduction of a bromine atom onto the double bond of the allylic bromide reverses the sense of diastereoselectivity in the [3,3]-sigmatropic rearrangement. Density functional theory calculations lead us to rationalise the observed selectivity in terms of a ...

5-Furan-2-yl[1,3,4]oxadiazole-2-thiol (Ia) and 5-furan-2-yl-4H-[1,2,4]-triazole-3-thiol (Ib) were synthesized from furan-2-carboxylic acid hydrazide. Mannich bases and methyl derivatives were then prepared. The structures of the synthesized compounds were confirmed by elemental analyses, IR and (1)H-NMR spectra. Their thiol-thione tautomeric equilibrium is described.

In the title compound, C14H17N3S, the plane of the phenyl ring makes a dihedral angle of 74.90 (4)° with that of the tri-aza-thione ring (r.m.s. deviation = 0.001 Å), while the seven-membered ring adopts a twist-chair conformation. No specific intermolecular interactions are discerned in the crystal packing.

Oraganometallic derivatives of palladium (o) have been isolated from the displacement reaction of Pd(Pφ3)4 with 1–substituted tetrazoline-5-thione with phenyl, orthotolyl, paratolyl, parachlorophenyl and benzoyl substitution in benzene medium. Most probable tetrahedral structure is assigned on the basic of elemental analysis, electronic, infrared, far infrared and 1H NMR spectral studies.

The synthesis of new indoloannulated thiopyranethiones is reported. key-step a rhodium-catalyzed [2 + 2 2]-cycloaddition alkynyl-ynamides with carbon disulfide to close the pyrrole and thiopyranethione rings simultaneously. A violet idolothiopyrane thione or mixture red isomer result from [RhCl(C8H14)2]2/3BINAP catalyzed cycloadditions, regiochemistry controlled by substitution pattern on alkyn...

thirty nine novel 1,2,3,4-tetrahydropyrimidinone (thione)s were subjected to conformational studies. density functional theory at b3lyp/6-31 g* was performed as the computational method of high accuracy. important dihedral angles and bond lengths were investigated and the values obtained were explainable. results of this work confirm a twisted boat tetrahydropyrimidine ring conformation with an...