OBJECTIVE The presence of antinuclear antibodies (ANA), directed against intracellular antigens, is a distinctive feature of systemic autoimmune rheumatic diseases (SARDs). The standard test for antinuclear antibody screening is the indirect immunofluorescence (IIF). Anti-dense fine speckled 70 (anti-DFS70) antibodies were initially identified as an ANA IIF pattern from a patient with interstit...

Antinuclear antibodies (ANAs) are a serological hallmark in the diagnosis of systemic autoimmune rheumatic diseases (SARD). The indirect immunofluorescence (IIF) assay on HEp-2 cells is a commonly used test for the detection of ANA and has been recently recommended as the screening test of choice by a task force of the American College of Rheumatology. However, up to 20% of apparently healthy i...

OBJECTIVE The aim of this study is to investigate the unique features of seronegative neuromyelitis optica spectrum disorders (NMOSD) in Thailand. BACKGROUND It remains unknown whether seronegative NMOSD patients possess clinical and paraclinical features that are distinct from those with seropositivity. METHODS In a Thai cohort of idiopathic inflammatory CNS disorders (n=122), 52 patients ...

The three-dimensional structure in solution of ferri-pyoverdin GM-I1 isolated from the culture medium of Pseudomonasfluorescens was determined by application of N M R methods to the Ga3+ analogue. Distance geometry calculations were performed with FILMAN using interproton distances and coupling constants as constraints. Further conformational analysis was carried out by energy minimization with...

The Information Inference Framework presented in this paper provides a general-purpose suite of tools enabling the definition and execution of flexible and reliable data processing workflows whose nodes offer application-specific processing capabilities. The IIF is designed for the purpose of processing big data, and it is implemented on top of Apache Hadoop-related technologies to cope with sc...

Background: Mycobacterium tuberculosis is a major cause of mortality and morbidity worldwide. Infection with this bacterium is known to induce the development of autoantibodies of which a few are also known to be diagnostic markers for some other diseases. Antineutrophil Cytoplasmic Antibodies (ANCA's) are among those autoantibodies used in clinical setting for diagnosing systemic vasculitic sy...

Twelve GPS Block IIF satellites, out of the current constellation, can transmit on three-frequency signals (L1, L2, L5). Taking advantages of these signals, Three-Carrier Ambiguity Resolution (TCAR) is expected to bring much benefit for ambiguity resolution. One of the research areas is to find the optimal combined signals for a better ambiguity resolution in geometry-free (GF) and geometry-bas...

Integration factor methods are a class of ‘‘exactly linear part’’ time discretization methods. In [Q. Nie, Y.-T. Zhang, R. Zhao, Efficient semi-implicit schemes for stiff systems, Journal of Computational Physics, 214 (2006) 521–537], a class of efficient implicit integration factor (IIF) methods were developed for solving systems with both stiff linear and nonlinear terms, arising from spatial...