نتایج جستجو برای: ii matrix
تعداد نتایج: 927794 فیلتر نتایج به سال:
The AML/CBFalpha runt transcription factors are key regulators of hematopoietic and bone tissue-specific gene expression. These factors contain a 31-amino acid nuclear matrix targeting signal that supports association with the nuclear matrix. We determined that the AML/CBFalpha factors must bind to the nuclear matrix to exert control of transcription. Fusing the nuclear matrix targeting signal ...
induce expression of active proteinases leading to increased matrix degradation. Other fragments increase matrix synthesis and cellular proliferation. Several studies have suggested that type II collagen fragments might influence chondrocyte differentiation in endochondral ossification, and we hypothesise that collagen II fragments might also promote cellular hypertrophy when they are over-prod...
BACKGROUND Glomerulonephritis is characterized by the accumulation of extracellular matrix protein within the glomerulus. This process, when allowed to proceed unimpeded, leads to glomerulosclerosis and eventually to cessation of glomerular filtration. There is evidence that protein kinase C (PKC) activation plays an important role in mediating at least some of the effects of TGF-beta in vascul...
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