To the Editor: D'Aloisio et al. report on IGF1 and IGFBP3 polymorphisms in relation to circulating insulinlike growth factor I (IGF-I) and insulin like growth factor binding protein-3 (IGFBP-3) plasma levels among African American and Caucasian women (CEBP 2009;18:954–66). In their study, mean IGF-I levels among Caucasian and African American were comparable. This is surprising because the Cauc...

BACKGROUND Responsiveness to GH treatment can be estimated by both growth and ∆IGF-I. The primary aim of the present study was to investigate if mimicking the physiological increase during puberty in GH secretion, by using a higher GH dose could lead to pubertal IGFs in short children with low GH secretion. The secondary aim was to explore the relationship between IGF-I, IGFBP-3 and the IGF-I/I...

Palabras clave: Opisthorchis viverrini. Colangiocarcinoma. Cholangiocarcinoma is one of the serious malignancies. It is a type of primary hepatobiliary tumor, there is a wide spectrum of tumors of varying differentiation and malignancy grades (1,2). It is the second most common primary cancer in the liver, and its incidence is highest in the northeastern part of Thailand (3). The etiology of th...

Methods Prepubertal children aged 3–10 years, (born at full term and not SGA) were recruited and grouped by birth order. All children had height, weight, body composition by DEXA scan and fasting serum IGF-1, IGF-2, IGFBP3, lipids, leptin, adiponectin, glucose and insulin levels recorded. Children’s heights and BMI were expressed as an SDS, and corrected for mean parental height and BMI SDS. A ...

Recently, we have shown that compared to controls, long-lived familial nonagenarians (mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate, and their middle-aged offspring displayed a lower prevalence of cardio-metabolic diseases, including diabetes mellitus. The evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway has been implicated in longevity in ...