BACKGROUND AND OBJECTIVE With the development of molecular biology in recent years, many indexes for detecting Epstein-Barr virus (EBV) have been developed. This study was to evaluate the diagnostic value of combined determination of EBV-related antibodies and antigens, including VCA-IgA, EA-IgA, EBV-DNase antibody and EBV-DNA, in diagnosing nasopharyngeal carcinoma (NPC). METHODS Serum and p...

BACKGROUND Individuals with irritable bowel syndrome (IBS) report abdominal pain, bloating, and diarrhea, symptoms similar to those in celiac disease. Studies suggest that the prevalence of celiac disease is increased in individuals with IBS; however, evidence is conflicting, and current guidelines do not always recommend screening for celiac disease in these individuals. METHODS We conducted...

Immunoglobulin A (IgA) provides protection against pathogens at mucosal surfaces. Chemotactic responses have been hypothesized to target IgA plasma cells involved in mucosal immune responses. We show here that thymus-expressed chemokine (TECK, CCL25) is a potent and selective chemoattractant for IgA antibody-secreting cells (ASC), efficiently recruiting IgA-producing cells from spleen, Peyer's ...

OBJECTIVES Serum immunoglobulin A-class tissue transglutaminase (tTG-ab) and endomysial antibody (EMA) tests play a key role in the diagnostic evaluation of celiac disease. Recently, a novel whole blood rapid test based on self-tissue transglutaminase (tTG) was developed for celiac disease case finding. Based on the same principle, a whole blood self-tTG enzyme-linked immunosorbent assay (ELISA...

background: helicobacter pylori (h. pylori), is a common infection in pregnant women accompanied by variations in the levels of the igm, iga and igg antibody isotypes. the variations of anti-h. pylori antibodies during and after pregnancy, and the extent of protection they provide to the mother and the fetus are not completely understood. objectives: to investigate the changes of the anti-h. py...

recurrent ear, nose, and throat (ent) infections are common presenting symptoms in patients with primary antibody deficiencies , but sometimes they remain undiagnosed for many years and are subjected to different antibiotics because of a lack of experience in immunodeficiencies. in order to determin the frequency of ent symptoms among the patients with antibody deficiencies, 83 antibody deficie...

The susceptibility of exocrine and serum immunoglobulins and antibodies to proteolytic degradation was assessed. Colostral and duodenal fluid exocrine 11S IgA, monomeric serum IgA, and IgG were digested with trypsin, chymotrypsin, or duodenal fluid. Exocrine IgA was more resistant to digestion than were the serum immunoglobulins. Under conditions of the experiments, most of colostral IgA retain...

Abstract We assessed the duration and baseline determinants of antibody responses to SARS-CoV-2 spike antigens occurrence reinfections in a prospective cohort 173 Spanish primary health care worker patients followed initially for 9 months subsequently up 12.5 after COVID-19 symptoms onset. Seropositivity receptor-binding domain 149–270 days was 92.49% (90.17% IgG, 76.3% IgA, 60.69% IgM). In sub...

background:â  northeastern iran has a high incidence for squamous cell esophageal carcinoma (escc). the aim of the study is to the assess relationship between celiac disease (cd) and escc. materials and methods:â  this was a two-part, cross-sectional, case-control study performed during 2006-2011 in gonbad, â golestan, iran. serum iga anti-tissue transglutaminase antibody levels were measured f...

BACKGROUND Antibody deficiency comprises a heterogeneous group of disorders characterised by the body's inability to mount an effective antibody response to pathogens. Although it has been reported that asthma and allergic disease are frequent in antibody deficiencies, there are no data that evaluate and compare bronchial hyperreactivity (BHR) in all groups of antibody deficiencies. In this stu...