background: idiopathic thrombocytopenic purpura (itp) is a disease that commonly affects women of reproductive age and is associated with maternal and fetal complications. objective: the aim of the present study was to report the perinatal outcome in pregnant women with itp. materials and methods: twenty one pregnant women with itp admitted in a teaching hospital in tehran, from october 2008 to...

Immune thrombocytopenic purpura (ITP) patients are at high risk for bleeding complications regarding surgeries involving cardiopulmonary bypass. We report an ITP patient with chronic thromboembolic pulmonary hypertension who underwent uncomplicated pulmonary endarterectomy with receiving postoperative intravenous immunoglobulin (IVIG) therapy. The positive outcome of this case may suggest that ...

hepatitis a is common in children and usually is a self-limiting disease.  although extrahepatic and hematological immune manifestations following acute hepatitis a virus (hav) infection have rarely been reported, they are frequently observed in other viral hepatitis. in this paper, we report the case of a 3-year-old girl who developed immune thrombocytopenic purpura (itp) and hemolytic anemia ...

A 27-year-old woman was admitted to our hospital with tetraparesis, dysesthesia and hypoesthesia of all regions below the breasts, urinary disturbance, and difficulty in breathing. Since age 21 idiopathic thrombocytopenic purpura (ITP) was diagnosed and steroid therapy was continued. At age 26, she had splenectomy for her ITP. On admission, steroid pulse therapy was administered with a tentativ...

The effects of B-cell depletion with rituximab on regulatory T cells (Tregs) have not been determined. We investigated Tregs in patients receiving rituximab for chronic idiopathic thrombocytopenic purpura (ITP). The peripheral blood Tregs, identified as CD4+FOXP3+ T cells, were measured by flow cytometry prior to and after the immunotherapy. In addition, Tregs were analyzed for their usage of t...

Spontaneous intracranial haemorrhage (ICH) is a rare complication of chronic immune thrombocytopenic purpura (ITP) in children. We report four patients with cITP who developed ICH. The latency between onset of ITP and ICH varied from 1-8 years. All our patients were profoundly thrombocytopenic (platelet count of <10 x 109/l) at the time of their intracranial bleed. The presenting features and m...