CCA-adding enzymes synthesize and maintain the C-C-A sequence at the tRNA 3'-end, generating the attachment site for amino acids. While tRNAs are the most prominent substrates for this polymerase, CCA additions on non-tRNA transcripts are described as well. To identify general features for substrate requirement, a pool of randomized transcripts was incubated with the human CCA-adding enzyme. Mo...

B.P.C. Kreukels et al. (eds.), Gender Dysphoria and Disorders of Sex Development: Progress in Care and Knowledge, Focus on Sexuality Research, DOI 10.1007/978-1-4614-7441-8_2, © Springer Science+Business Media New York 2014 Abstract The development of gender identity, its variance, and gender dysphoria is thought to be a complex process involving biological and psychosocial factors. Heritabilit...

Environmental challenges are often marked by an intergroup dimension. Political conservatives and progressives are divided on their beliefs about climate change, farmers come into conflict with scientists and environmentalists over water allocation or species protection, and communities oppose big business and mining companies that threaten their local environment. These intergroup tensions are...

How humans extract the identity of speech sounds from highly variable acoustic signals remains unclear. Here, we use searchlight representational similarity analysis (RSA) to localize and characterize neural representations of syllables at different levels of the hierarchically organized temporo-frontal pathways for speech perception. We asked participants to listen to spoken syllables that dif...

The ovine CD4 cDNA sequence from four sheep sources (Australian Merino, Indonesian Thin Tail, Canadian cross bred, Prealpes du sud) predicts a protein of 455 residues with position 130 in the V2 domain exhibiting a W instead of C suggesting that, like the white whale, dog and cat sequences, sheep CD4 contains only two disulphide bonds. The sequence shows 73% amino acid identity and 83% nucleoti...

This working paper is produced for discussion purposes only. The papers are expected to be published in due course, in revised form and should not be quoted without the author's permission. Management's optimal financial contracts, the degree of alignment with investors, and the 'carrot and stick' role of debt. Are you still here?: Reconciling patient access and GP effectiveness in the manageme...

in this paper, the concept of {sl local base with  stratifiedstructure} in $i$-topological vector spaces is introduced. weprove that every $i$-topological vector space has a balanced localbase with stratified structure. furthermore, a newcharacterization of $i$-topological vector spaces by means of thelocal base with stratified structure is given.

Locked nucleic acids (LNA) show remarkable affinity and specificity against native DNA targets. Effects of LNA modifications on mismatch discrimination were studied as a function of sequence context and identity of the mismatch using ultraviolet (UV) melting experiments. A triplet of LNA residues centered on the mismatch was generally found to have the largest discriminatory power. An exception...

the present study is aimed at assessing the state of national identity among female students of ahwaz islamic azad university and explores the social factors affecting upon it. the statistical society consisted of 8532 students at the three levels of associate diploma undergraduate and master degrees. the research method in this study is a “survey” and collection of data has been carried out by...