Background Comprehensive analysis of transcriptomic profiles non-small cell lung cancer (NSCLC) may provide novel evidence for biomarkers associated with response to PD-1/PD-L1 immune checkpoint blockade (ICB). Methods We utilized weighted gene co-expression network (WGCNA) analyze data from two NSCLC datasets Gene Expression Omnibus (GSE135222 and GSE126044) that involved patients received ICB...

Isothermal compression bonding (ICB), or high temperature plastic deformation bonding, has become a prospective solid phase technique without risk of casting defects in the joints compared to conventional welding. In this study, rare-earth magnesium alloy is subjected ICB process under range thermo-mechanical processing parameters. The results show that large grains and low grain orientation sp...

Integrating Concepts in Biology (ICB) is the apt title of this groundbreaking electronic textbook (see Supplemental Material). The target audience is students seeking an introduction to biology. It is structured to focus student attention on key concepts underlying biology at all levels of organization. In contrast to the current encyclopedic model of an introductory textbook, this e-book makes...

The Earth’s core consists of a solid ball with a radius of 1221 Km, surrounded by a liquid shell which extends up to 3480 km from the center of the planet, roughly half way toward the surface the mean radius of the Earth is 6373 km . The main constituent of the core is iron, and therefore the melting temperature of iron at the pressure encountered at the boundary between the solid and the liqui...

We redesigned the undergraduate introductory biology course by writing a new textbook (Integrating Concepts in Biology [ICB]) that follows first principles of learning. Our approach emphasizes primary data interpretation and the utility of mathematics in biology, while de-emphasizing memorization. This redesign divides biology into five big ideas (information, evolution, cells, emergent propert...

To investigate the expression profiles of efflux transporters in human ocular tissues, quantitative real-time polymerase chain reaction, Western blotting, and immunohistochemistry were used to obtain the relative mRNA and protein expressions of various efflux transporters in human ocular tissues. The cornea, conjunctiva, irisciliary body (ICB), retina and choroid, human corneal epithelial cell ...

In this study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) of differentiation-associated human gene icb-1 (C1orf38) may be associated with ovarian cancer susceptibility. For this purpose, we compared the genotype and allele frequencies of the SNPs rs1467465 and rs12048235 in a group of 184 ovarian cancer patients with a control group of 184 age- and gender-matched women...

Background. New oral anticoagulants (NOAC; rivaroxaban, dabigatran, apixaban) have become available as an alternative to warfarin anticoagulation in non-valvular atrial fibrillation (NVAF). Methods. MEDLINE and CENTRAL, regulatory agencies websites, clinical trials registers and conference proceedings were searched to identify randomised controlled trials of NOAC versus warfarin in NVAF. Two in...