A linkage disequilibrium-based method for fine mapping quantitative trait loci (QTL) has been described that uses similarity between individuals' marker haplotypes to determine if QTL alleles are identical by descent (IBD) to model covariances among individuals' QTL alleles for a mixed linear model. Mapping accuracy with this method was found to be sensitive to the number of linked markers that...

the inflammatory bowel diseases (ibd) have been found to accompany some neurological syndromes including multiple sclerosis (ms). recently, several studies have reported and discussed the simultaneous presence of ibd and ms in some patients. thus, in patients with either disease, the presence of signs and symptoms of the other should raise the clinical suspicion of the clinician and warrant spe...

Background: Blastocystis is the most common anaerobic protozoa living in the large intestine of a broad spectrum of vertebrates. Objectives: The aim of this study was to investigate the Blastocystis infection rate in inflammatory bowel disease (IBD) patients. Methods: A total of 80 stool samples were collected from IBD-proved patients. All stool samples were cultivated in Dulbecco’s modified Ea...

Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian fe...

AIM To analyze clinical differences between monogenic and nonmonogenic very-early-onset inflammatory bowel disease (VEO-IBD) and to characterize monogenic IBD phenotypically and genotypically via genetic testing. METHODS A retrospective analysis of children aged 0 to 6 years diagnosed with VEO-IBD in a tertiary hospital in southern China from 2005 to 2017 was performed. Clinical data for VEO-...

BACKGROUND Mast cells have been shown to regulate intestinal ion transport in animal models and normal human colon but their physiological role in human intestinal inflammatory disorders is unknown. AIMS To examine mast cell regulation of ion transport in inflammatory bowel disease (IBD). SUBJECTS AND METHODS Small and large intestine was obtained from patients with and without IBD undergoi...

BACKGROUND The objective of this study was to measure the prevalence of inflammatory bowel disease (IBD) among patients with autism spectrum disorders (ASD), which has not been well described previously. METHODS The rates of IBD among patients with and without ASD were measured in 4 study populations with distinct modes of ascertainment: a health care benefits company, 2 pediatric tertiary ca...

(AOCC) and designed for one program of the 2 annual AOCC meeting, which was held in Seoul, Korea in June 2014. The aim of the survey was to identify how Asian physicians diagnose and treat their IBD patients. A survey to determine differences in public medical insurance systems and the quality of care across countries was also performed. This survey consisted of 4 parts including general inform...

Inflammatory bowel disease (IBD) is a disease that affects the intestinal tract via an inflammatory process. Patients who suffer from IBD often have diseases that affect multiple other organ systems as well. These are called extraintestinal manifestations and can be just as, if not more debilitating than the intestinal inflammation itself. The skin is one of the most commonly affected organ sys...

BACKGROUND AND PURPOSE The SNP R30Q (rs1248696) within the discs large homolog 5 (DLG5) gene has been associated with inflammatory bowel disease (IBD). In this study, we examined the genetic association of another DLG5 SNP P1371Q (rs2289310) with IBD and its interaction with R30Q in disease susceptibility. METHODS A total of 213 IBD patients [106 familial; 59 Crohn's disease (CD) and 47 ulcer...