Background: The immune antigen of Bacillus anthracis is a protein that can attach to the surface receptor of all human cells. At the surface of cancer cells, there is a receptor that activates the uPA (Urokinase plasminogen) that do not exist in normal human cells. Objectives: The aim of this study was changing the location of the attachment of the PA gene by a dir...

the androgen insensitivity syndrome is a heterogeneous disorder with a wide spectrum of phenotypic abnormalities, ranging from complete female to ambiguous forms that more closely resemble males. the primary abnormality is a defective androgen receptor protein due to a mutation of the androgen receptor gene. this prevents normal androgen action and thus leads to impaired virilization. a point m...

the present study , was an attempt to develop galactosylated albumin nanoparticles of simvastatin for treatment of hypercholesterolemia. by developing the galactosylated nanoparticulated delivery the required action of drug at the target site at liver can be provided. the advantage of targeting helps to reduce the systemic side effects which may be occur due to the distribution of the drug to t...

Probiotics have great potential in regulating intestinal pain. In this study, the effects of Lactobacillus plantarum AR495 on visceral sensitivity and gut microbiota irritable bowel syndrome (IBS) rats were studied. The results showed that tryptase released after mast cell activation degranulation plays a key role pain, L. reduced stimulation colonic cells expression protease-activate...

Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...

Background NMDA receptor (NMDAR) malfunctioning has been claimed as a crucial event in Alzheimer’s disease (AD), the most common form of dementia. While synaptic NMDAR activation leads to plasticity, extrasynaptic excitotoxicity, mitotoxicity and cell death. In late onset AD, APOE4 allele is main genetic risk factor. Our aim study influence apoE4 on function. Method We isolated membranes from A...