Intestinal epithelial cells (IEC) act as an important intestinal barrier whose function can be impaired upon induction by hypoxia. Although injuries are preventable milk-derived exosomal microRNAs (miRNAs), the underlying mechanism remains poorly understood. This study aimed to characterize effect of yak and cow milk–derived miRNA on IEC-6 under hypoxic conditions, explore milk relieve hypoxia ...

Ooi, Henry, Elaine Cadogan, Michèle Sweeney, Katherine Howell, R. G. O’Regan, and Paul McLoughlin. Chronic hypercapnia inhibits hypoxic pulmonary vascular remodeling. Am. J. Physiol. Heart Circ. Physiol. 278: H331–H338, 2000.—Chronic hypercapnia is commonly found in patients with severe hypoxic lung disease and is associated with a greater elevation of pulmonary arterial pressure than that due ...

introduction: oxygen tension is one of the most important stimuli in stem cell biology. in this study, we investigate the considerable influence of hypoxia on cx43 gene expression as one of the most important gap junction on the surface of mesenchymal stem cells. methods: mesenchymal stem cells were isolated from c57bl/6 mouse bone marrow and cultured in dmem medium under low oxygen tension (1%...

Many cells in the human body strongly react on decreased oxygen concentrations, generally defined as hypoxia. Therefore, inducing hypoxia vitro is essential for research. Classically, induced using a chamber, but alternative methods exist that do not require special equipment. Here, we compared three different to induce without chamber: chemical stabilization of HIF-1? by CoCl2, decrease perice...

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Despite the fact that photodynamic therapy (PDT) has promising clinical prospects, its therapeutic efficacy is still restricted by hypoxic tumor microenvironment (TME). Therefore, how to suitably employ hypoxia vital for optimizing PDT. Herein we developed a hypoxia-activated prodrug combination with A hypoxia-responsive camptothecin (CPT)-based and near-infrared (NIR) BODIPY photosensitizer we...

This symposium was organized to present research dealing with the effects of intermittent hypoxia on cardiorespiratory systems and cellular mechanisms. The pattern of neural impulse activity has been shown to be critical in the induction of genes in neuronal cells and involves distinct signaling pathways. Mechanisms associated with different patterns of intermittent hypoxia might share similar ...

Submerged hippocampal slices were exposed to 30 minutes of moderate or mild hypoxia at 29 degrees C and then reoxygenated. Synaptic transmission was lost at the same rate in response to either grade of hypoxia, but recovery was faster following mild hypoxia. Hyperexcitability of synaptic transmission was a lasting feature following moderate hypoxia, but it was transient following mild hypoxia; ...