BACKGROUND/AIMS Long non-coding RNAs (lncRNAs) are thought to play crucial roles in human diseases. However, the function of lncRNAs in hypertrophic scar formation remains poorly understood. METHODS In this study, we investigated the expression of lncRNA8975-1 in hypertrophic scar tissues and fibroblasts by quantitative reverse transcription PCR (qRT-PCR). To investigate its function, overexp...

structive hypertrophic cardiomyopathy. J Clin Invest 66: 1369, 1980 30. Stefadouros MA, Canedo MI, Karayannis E, Abdulla A, Frank MJ: Internally recorded systolic time intervals in hypertrophic subaortic stenosis. Am J Cardiol 40: 700, 1977 31. Nesje OA, Enge I: External carotid pulse recordings in hypertrophic obstructive cardiomyopathy. Acta Med Scand 202: 197, 1977 32. Henry WL, Clark CE, Gr...

The transcription factor NF-kappaB regulates expression of genes that are involved in inflammation, immune response, viral infection, cell survival, and division. However, the role of NF-kappaB in hypertrophic growth of terminally differentiated cardiomyocytes is unknown. Here we report that NF-kappaB activation is required for hypertrophic growth of cardiomyocytes. In cultured rat primary neon...

The topography and specificity of fibre disarray and fibrosis in hypertrophic obstructive cardiomyopathy were determined in a histological study comprising 40 necropsy hearts--10 with hypertrophic cardiomyopathy, 10 with congestive cardiomyopathy, 10 with aortic valve stenosis, and 10 normal hearts. Seven standard regional sections were sampled from each heart and graded "double-blind" (tissue ...

Calcineurin is a Ca(2+)/calmodulin-activated protein phosphatase that transduces hypertrophic stimuli to regulate transcriptional control of myocyte transformation. It is not known whether overexpression of MCIP1, a recently described endogenous inhibitor of calcineurin, impacts the hypertrophic response to pathophysiologically relevant pressure overload. Further, the functional consequences of...

Apical hypertrophic cardiomyopathy is characterized by a spade-like left ventricular cavity and by both giant negative T waves and tall R waves in the electrocardiogram. However, the mechanisms of these ECG abnormalities have not been satisfactorily clarified. We have recently developed a three-dimensional computer model of ventricular depolarization and repolarization processes. This model has...

Apical hypertrophic cardiomyopathy is an uncommon variant of hypertrophic cardiomyopathy, with hypertrophy mainly affecting the apex of the left ventricle. We hereby describe a case of an octogenarian female patient who was randomly diagnosed with AHCM due to other comorbidities.

Formin Homology 2 Domain Containing 3 Variants Associated With Hypertrophic Cardiomyopathy Eric C. Wooten, PhD; Virginia B. Hebl, MD; Matthew J. Wolf, MD, PhD; Sarah R. Greytak, PhD; Nicole M. Orr, MD; Isabelle Draper, PhD; Jenna E. Calvino, BA; Navin K. Kapur, MD; Martin S. Maron, MD; Iftikhar J. Kullo, MD; Steve R. Ommen, MD; J. Martijn Bos, MD, PhD; Michael J. Ackerman, MD, PhD; Gordon S. Hu...

Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic hypertrophic state. The restricted and reciprocal expression of the collagen X gene, Col10a1, in hypertrophic chondrocytes and Sox9 in immature chondrocytes epitomise the precise spatiotemporal control of gene expression as chondrocytes progres...

BACKGROUND The present retrospective cohort study was performed to determine the efficacy of contact-mode 1064 nm neodymium-yttrium-aluminum-garnet (Nd:YAG) laser laser for keloids and hypertrophic scars. The indication and limitations of this modality are discussed. METHODS The cohort consisted of 102 consecutive Japanese patients (23 males and 79 females) with keloids and hypertrophic scars...