Cyclosporin A (CsA), an immunosuppressant, is known to exhibit hypertrichosis as a side effect. This compound prolongs human hair growth in follicle organ culture system. Thus, CsA has anagen-prolonging activity, but the mechanism of action unclear. In immunosuppression, binds cyclophilin (CyP) form complex that inhibits activity phosphatase, calcineurin (CaN), which turn nuclear translocation ...

"Don Pedro Gonzales, the “wild man,” as he was nicknamed by his contemporaries, suffered from hypertrichosis, a rare disease that caused uncontrollable growth of hair on face and all over body. Until now, truly little known about life, especially stay at court kings France. New documents found in French archives show despite illness, not only managed to lead normal life with wife children, but ...

A 14 year old female presented with a patch of hair on her lower back since infancy (Figure 1). There was history of prolonged low backache. The antenatal and birth history was uneventful. Developmental milestones achieved by her were normal for age. There was no history of urinary or fecal incontinence or lower limb weakness. On examination, a well-defined patch of terminal, dark hair was note...

We report the case of a 16-month-old girl with hypomelanosis of Ito, a relatively rare phenotype associated with neurocutaneous manifestations. The characteristic hypopigmented streaks along the Blaschko lines were associated with hypertrichosis of the genitals and shins, as well as musculoskeletal and dental anomalies. An underlying endocrinologic disorder of the hypertrichosis could be exclud...

Congenital Hypertrichosis Lanugionsa is a rare autosomal dominant genetic disorder, with fewer than 50 cases reported in the literature. It is characterized by excessive lanugo hair, sparing only the mucous membranes, palms and soles. It may be associated with other organic abnormalities and should form part of the dermatologist's current knowledge. We discuss some aspects of the syndrome in qu...

We report the case of a 7-month-old girl with atypical oculo-facio-cardio-dental syndrome (OFCD). A novel de novo pathogenic mutation in the BCL6 interacting co-repressor gene (BCOR) (c.4540C>T; p.Arg1514*), was identified on the X chromosome. This case expands the phenotype of OFCD as it is the first report of a case presenting with craniosynostois, temporal hypertrichosis, supraorbital groovi...