‘Drug Induced Hypersensitivity Syndrome’ (DiHS) or Rash with Eosinophilia and Systemic Symptoms’ (DRESS) syndrome is a life threatening, delayed type drug hypersensitivity reaction. This characterized by fever, skin rash, lymphadenopathy, hematological abnormalities visceral involvement liver the most frequently involved organ. Liver mostly presented as acute anicteric hepatitis elevated enzyme...

T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances in pharmaco...

Introduction: Different types of allergic conditions develop in the half of patients infected with HIV due to the immune system dysfunction. Increased prevalence of allergic conditions in HIV infected patients lead us to conduct the study of allegro reactivity by carrying out skin tests to different types of allergens including an allergen to Candida. Objective: To study the immediate type skin...

Hypersensitivity reactions to methotrexate are rare, but have been reported. Methotrexate has shown activity against many malignancies, and omission of methotrexate therapy may increase the risk of cancer-related death in some patients. Therefore, rechallenging patients with methotrexate following hypersensitivity may be beneficial. We report a case of a child with metastatic osteosarcoma who e...

The fruitfulness of biofertilizer application in increasing plant growth and yield is when the formulation uses selected microbial isolates that do not cause disease to plants. Hypersensitivity test carried out ensure used are pathogenic purpose this study was determine pathogenicity three potassium solubilizing bacteria (KSB) (BPK-DHJ3-3150[17], BPK-DHJ1-4125[2], BPKDHJ2-5250[16]) isolated fro...

OBJECTIVES The purpose of this retrospective study was to ascertain the clinical safety of administering carbapenems, namely imipenem/cilastatin and meropenem, in patients with a history of penicillin allergy compared with administering carbapenems in patients with no reported penicillin allergy. Carbapenems are similar in chemical structure to the penicillins and therefore are associated with ...

BACKGROUND The liver is the most commonly involved internal organ in drug-induced systemic hypersensitivity. However, data obtained from these patients have yet to be analyzed in depth with respect to liver injury. METHODS The medical records of 136 patients who developed delayed-type drug hypersensitivity were reviewed at a tertiary referral hospital. Culprit drugs, the pattern and degree of...