Bilateral destructions of a well localised area in lateral hypothalamus led to complete cessation of eating, while lesions involving ventromedial nuclei or the region between these and lateral area produced hyperphagia and obesity. The lateral region (hunger mechanism) was designated 'feeding center' and the medial (inhibitory control) 'satiety center.' [The SCI indicates that this paper has be...

Kleine-Levin syndrome (KLS) is a rare disease characterized by recurrent episodes of hypersomnia, compulsive hyperphagia and behavioral disorders. KLS affect predominantly male adolescents. We report an unusual presentation of KLS at an early age refractory to a variety of therapeutics and finally controlled with lithium.

This is a case of Kleine-Levin Syndrome, which is described in a teenage girl who presented with features of hypersomnolence, hyperphagia, and hypersexuality. The patient‘s initial presentation was with academic decline due to excessive somnolence, which was recurrent in nature. She was started on stimulants and lithium medications, to which she showed favorable response (German J Psychiatry 20...

Kleine-Levin syndrome (KLS) is an episodic hypersomnia with cognitive disturbances such as confusion, apathy, and derealization. Hyperphagia and hypersexuality occur in around 50% of cases. No evidence-based treatments have been established for KLS. Many drugs have been tried, most often with little success. Here, a case with a striking response to lithium is presented.

Prader-Willi syndrome, induced by a function changes of paternal genes in the subcentrometric region of the chromosome 15 (q11.2q13), is the most common genetic cause of obesity resulting from hyperphagia. Behavioural disturbancies with compulsions in which psychiatric interventions are necessary, are relatively frequently seen. In this paper we reviewed the recent data of the clinical diagnosi...

Snack food like potato chips substantially contributes to energy intake in humans. In contrast to basic food, snacks are consumed additionally to other meals and may thereby lead to non-homeostatic energy intake. Snack food is also frequently associated with hedonic hyperphagia, a food intake independent from hunger. Analysis of brain activity patterns by manganese-enhanced MRI has previously r...

BACKGROUND AND AIMS Intestinal adaptation after small bowel resection in humans is debated. We have quantified in adult short bowel (remnant small bowel length <2 m) patients oral intake and net digestive absorption and their evolution over time. PATIENTS AND METHODS Oral intake and faecal output were studied over three days in 90 patients (39 and 51 without or with parenteral nutrition, resp...

Mice with a targeted disruption of bombesin receptor subtype-3 (BRS-3 KO) develop hyperphagia, obesity, hypertension, and impaired glucose metabolism. However, the factors contributing to their phenotype have not been clearly established. To determine whether their obesity is a result of increased food intake or a defect in energy regulation, we matched the caloric intake of BRS-3 KO mice to wi...

Following smoking cessation, individuals increase their food intake. Women experience greater postcessation hyperphagia than men, and older women may increase their food intake more than younger women. Some research has suggested that postcessation increases in food intake may be macronutrient specific. However, previous investigations of macronutrient specific changes in food intake following ...

The obesity described by Babinski,2 Fr'ohlich,18 and Erdheim16 in patients suffering from lesions at the base of the brain has now been produced experimentally in the dog,20 24 cat,32 monkey,9 and rat.6 8 Moreover, the long-existing controversy as to whether the primary lesion is in the hypophysis4' 12, 18 (as originally suggested by Fr'ohlich"8) or in the hypothalamus16 22, 30 (as Erdheim"6 fi...