Background and Aims: Hypericum microcalycinum Boiss. & Heldr. is used for inflammatory diseases in Anatolia. The involvement of liver X receptors (LXRs) free radicals diseases, activation LXRs, high radical contents cancerous tissue organs prompted us to determine the scavenging LXRα agonist activity aqueous fraction methanol extract fractions H. along with isolation studies from active fracti...

Acetylcholinesterase (AChE) is responsible for hydrolyzing the acetylcholine neurotransmitter, bringing an end point to cholinergic neurotransmission. Thus, AChE primary target of a wide spectrum compounds used as pesticides, nerve agents or therapeutic drugs neurodegenerative diseases such Alzheimer’s disease (AD). This enzyme heterogeneously distributed in brain showing different activity dep...

The value of an extract of Hypericum perforatum (St John's wort) for children with mild to moderate depressive symptoms was investigated for the first time in a multi-centre post-marketing surveillance study. One hundred and one children under 12 years were treated for a minimum of 4 weeks with an extension to 6 weeks with parental consent and medical practitioner recommendation. the dosage use...

Objective: Phthalates, despite their endocrine disrupting effects, are widely used as plastifiants. Environmental exposure of phthalates was demonstrated to cause fetal death and reproductive toxicity in human beings, well laboratory animals. However, underlying mechanisms not clear.
 Material Methods: Here, we examine the impact di(2-ethylhexyl) phthalate (DEHP) dibutyl (DBP)on rat lungs,...

background & aim:hypericum perforatum l. is native to iran. this herb is one of the most important medicinal plants and had many medical effects.this experiment was conducted to investigate the effects of feeding hypericum perforatum and protexin on performance, carcass characteristics and intestinal morphology japanese quails. experimental: a total of 240 ten days old quails were divided into ...

T^ has been no complete organ blood volume study for any animal, nor any definitive total body blood volume determination for the rat. Thus, an extensive study was undertaken to determine the normal red cell and plasma volumes of the whole rat and for each of its major organs or tissues. This study is a prerequisite to investigations concerned with the effect of various experimental procedures ...

We have previously demonstrated that diphenylarsinic acid (DPAA) promotes liver carcinogenesis in rats in a medium-term liver carcinogenicity bioassay. However, the effects of DPAA on other organs have not been determined. In the present study, the effects of DPAA on carcinogenesis were investigated using a rat multiorgan carcinogenicity bioassay. A total of 60 six-week-old male F344 rats were ...