St. John’s wort (SJW)(Hypericum perforatum L) is one of the oldest medicinal herbs. Hypericum extracts have been shown to be significantly effective in treating mild to moderate depression. To our knowledge, this is the first case report about panic attack in a man induced by a single dose of SJW extract. A 35-year-old male was admitted for gradually increased trembling and fear of dying. He st...

BACKGROUND Anthrax is a zoonotic disease caused by Bacillus anthracis, a Gram-positive spore-forming bacterium. The presence of the bacteria and the toxins in the blood of infected hosts trigger a cascade of pathological events leading to death. Nine medicinal plants with good activities against other bacteria were selected to determine their in vitro antibacterial activity against Bacillus ant...

BACKGROUND Hypericum is a well-known plant genus in herbal medicine. Hypericum mysorense (Family: Hypericaceae), a plant belonging to the same genus, is well known in folklore medicine for its varied therapeutic potential. OBJECTIVE The aim of the present study was to investigate the different parts of the plant for antioxidant and hepatoprotective properties. MATERIALS AND METHODS The meth...

BACKGROUND Major depressive disorder (MDD) is the most common disorder in our community. Hypericum perforatumm, is a herb with a long application history in treating depression. A controlled study to evaluate the effects of this herbal medicine in Iran did not exist. OBJECTIVES This study aimed to assess the effect of Hypericum perforatom (perforan), in combination with tricyclic antidepressa...

The synthesis of the unique furo[2,3-b]chromene ring system found in hyperaspidinols A and B, acylphloroglucinols from Hypericum chinense has been achieved in twelve steps. By comparison of the NMR spectra of the synthesized compounds with those of the natural products, a relative stereochemistry is suggested, especially that of the ketal carbon.

background : with regard to an increase in the life expectancy for women and the consistency of the menopause age, a significant portion of women's age is passed after the menopause. menopause is considered as a critical and sensitive period due to the changes and the disorders that are involved in it. vasomotor symptoms, sleep disorders and psycho-mental changes are among the most prevalent sy...

Extracts of Hypericum perforatum (St. John’s Wort) are widely used for the treatment of depressive disorders and are unspecific inhibitors of the neuronal uptake of several neurotransmitters. Previous studies have shown that hyperforin represents the reuptake inhibiting constituent. To characterize the mechanism of serotonin reuptake inhibition, kinetic analyses in synaptosomes of mouse brain w...