apparent rise in the incidence of infertility in females and the trend shifting towards delayed child bearing brought up the concept of ovarian ageing. women in their early thirties show poor ovarian reserve which is an entity named as early ovarian ageing. early ovarian ageing is mostly genetically determined, but acquired modifiable factors like smoking, or ovarian surgery have some roles. in...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. We read with interest the commentary by Dr. Pandiyan and colleagues (1) about the merit of our recently published clinical practice guidelines for sperm DNA fragmentation (SDF) testing based on clinical scenarios (2). We noted that these authors were quite skeptic about the integration of SDF testing into the clinical...

Although several genetic causes of male infertility are known, the condition in around 60.0-75.0% of infertile male patients appears to be idiopathic. In some, genetic causes may be polygenic and require several low-penetrance genes to produce a phenotype outcome. In others, pleiotropy, when a gene can produce several phenotypic traits, may be involved. We have investigated whether single nucle...

Male factor infertility or subfertility is responsible for up to 50% of infertility cases. A considerable body of recent studies indicates that lifestyle as well as environmental and psychological factors can negatively affect male fertility, more than previously thought. These negative effects have been shown in many cases to be reversible. This review aims to provide a rationale for early cli...

Background This study was designed to create an experimental varicocele model by a simple surgical procedure in dog with minimum invasion and to investigate the effect of varicocele-induced infertility on the expression of six related genes (HSP90, HSP70, IL- 4, TNF, KITLG and KIT receptor). MATERIALS AND METHODS In this experimental study, the proximal part of the pampiniform plexus of dog t...

STUDY QUESTION Is asthma more common in children born after subfertility and assisted reproduction technologies (ART)? SUMMARY ANSWER Yes. Asthma, wheezing in the last year and anti-asthmatic medication were all more common in children born after a prolonged time to conception (TTC). This was driven specifically by an increase in children born after ART. WHAT IS KNOWN ALREADY Few studies ha...

Brucella ovis is a major cause of epididymitis in sexually mature rams, resulting in subfertility, infertility, and economic losses for the sheep industry worldwide. The aim of this study was to develop an indirect ELISA (iELISA) using recombinant proteins, namely rBoP59 and rBP26, as antigens for serological diagnosis of B. ovis infection. The BoP59 and BP26 recombinant proteins were expressed...

OBJECTIVE To study the effect of cigarette smoking on seminal fluid parameters, namely; volume, sperm concentration, and motility, as well as morphology, leukocyte infiltration, among males complaining of infertility. METHODS Between August 2010 and July 2011, seminal fluid analysis was done for 1438 males who are partners of couples who visited the infertility clinic at Prince Rashid Ben Al ...

OBJECTIVE To assess the utility of HOMA-IR in assessing insulin resistance in patients with polycystic ovary syndrome (PCOS) and compare it with fasting insulin for assessing insulin resistance (IR). STUDY DESIGN Observational study. PLACE AND DURATION OF STUDY Section of Clinical Chemistry, Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, from Jan...

Introduction nfertility is defined as the inability of a couple to achieve conception after one year of regular unprotected coitus'. Sterility implies an intrinsic inability to achieve pregnancy, whereas infertility implies a disease in the ability to conceive and is synonymous with subfertility. Approximately 90% of couples with unprotected intercourse will conceive within 1 year and sterility...