نتایج جستجو برای: hyperactivation
تعداد نتایج: 2165 فیلتر نتایج به سال:
Data on factors contributing to the development of postoperative cardiac complications (myocardial infarction, heart failure, arrhythmias) in non-cardiosurgical operations are presented. Hypotension and blood loss usually distinguished among such factors, but less attention is paid role neuroendocrine reactions, particular, hyperactivation sympathoadrenal system; protective effect anesthesia, r...
IMPORTANCE Bipolar disorder (BD) is a debilitating mental illness associated with high costs to diagnosed individuals and society. Within the past 2 decades, increasing numbers of children and adolescents have been diagnosed as having BD. While functional magnetic resonance imaging (fMRI) studies have begun to investigate the neural mechanisms underlying BD, few have directly compared differenc...
Neurons adapt to altered network activity through homeostatic changes in synaptic function. In this issue of Neuron, Goold and Nicoll report that chronic hyperactivation of individual CA1 pyramidal neurons drives cell-autonomous, compensatory synapse elimination via CaMKIV-dependent transcription. These findings suggest that neurons gauge their intrinsic activity to instruct homeostatic regulat...
B cells are selected for an intermediate level of B cell receptor (BCR) signaling strength: Attenuation below minimum (e.g. non-functional BCR)1 or hyperactivation above maximum (e.g. self-reactive BCR)2–3 thresholds of signaling strength causes negative selection. In ~25% of cases, acute lymphoblastic leukemia (ALL) cells carry the oncogenic BCR-ABL1 tyrosine kinase (Ph+), which mimics constit...
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