UNLABELLED Hierarchically nanosized hydroxyapatite (HA) with flower-like structure assembled from nanosheets consisting of nanorod building blocks was successfully synthesized by using CaCl(2), NaH(2)PO(4), and potassium sodium tartrate via a hydrothermal method at 200°C for 24 hours. The effects of heating time and heating temperature on the products were investigated. As a chelating ligand an...

In this study, we investigated the effects of temozolomide (TMZ)/Poly (lactide-co-glycolide)(PLGA)/nano-hydroxyapatite microspheres on the behavior of U87 glioma cells. The microspheres were fabricated by the "Solid/Water/Oil" method, and they were characterized by using X-Ray diffraction, scanning electron microscopy and differential scanning calorimetry. The proliferation, apoptosis and invas...

PURPOSE This observational study examined the resorptive behavior of normal neonatal rabbit osteoclasts grown on slices of bovine cortical bone as compared to samples of commercially available bone substitute biomaterials. It also examined the surface characteristics of these materials. MATERIALS AND METHODS The 11 materials tested fell into 3 groups: (1) bone-derived, including freeze-dried ...

The advancement of science is leading humanity to a new aeon: the era of nanotechnology. In simple terms, it refers to the technology exercised on materials at molecular level (less than 100 nanometers) (1). Foundation stone of this looming phase in dentistry was laid by Richard Feynman in 1959, a noble prize winning physicist (1). Nanotechnology has brought upon exorbitant changes in all persp...

This thesis is part of the ANR project PNano NANOBONEFILLER. The aim of this project is the development of a new injectable bone filling system based on mesoporous calcium phosphates associated with growth factors. The thesis is composed of two main parts: the synthesis of mesoporous calcium phosphates by hard templating techniques and the adsorption and release of growth factors on these porou...

Hydroxyapatite, the main mineral phase of mammalian tooth enamel and bone, grows within nanoconfined environments and in contact with aqueous solutions that are rich in ions. Hydroxyapatite nanopores of different pore sizes (20 Å ≤ H ≤ 110 Å, where H is the size of the nanopore) in contact with liquid water and aqueous electrolyte solutions (CaCl2 (aq) and CaF2 (aq)) were investigated using mol...

Doping calcium phosphates with ionic species can play an important role in biological responses promoting alkaline phosphatase activity, and, therefore inducing the generation of new bone. Thus, in this study, the synthesis of niobium-doped hydroxyapatite (Nb-HA) nanosize particles obtained by the precipitation process in aqueous media followed by thermal treatment is presented. The bioceramics...

to bone are concerned are brittle materials as exempliŽ ed by hydroxyapatite and ‘Bioglass’. Bioactive coatings are This paper reports on an investigationof the potential employed on metal implants to facilitate bonding to bone use of high energy ball milling (HEBM) for the while retaining the good combination of mechanical production of homogeneous mixtures of titanium/ properties associated w...

Combination of nano‐sized hydroxyapatite (nHA) with restorative materials like glass ionomer cement and composite resins has been reported recently in 2011. The documented effects of these nano‐sized particles on the chemistry of these materials include increased biocompatibility and mechanical strength. nHA has been utilized for various applications like pulp capping agent, root canal sealer, ...