A novel mucoadhesive buccal tablet containing flurbiprofen (FLB) and lidocaine HCl (LID) was prepared to relieve dental pain. Tablet formulations (F1-F9) were prepared using variable quantities of mucoadhesive agents, hydroxypropyl methyl cellulose (HPMC) and sodium alginate (SA). The formulations were evaluated for their physicochemical properties, mucoadhesive strength and mucoadhesion time, ...

The present study deals with the formulation and of oromucosal tablets Rizatriptan Benzoate (RB) using different bioahdesive polymer. Nine formulations were prepared by direct compression method. Hydroxypropyl methyl cellulose (HPMC K4M), Gum acacia Sodium Alginate used as buccal mucoadhesive Ethyl (EC) an impermeable backing layer. FTIR Studies showed no interaction drug, polymer excipients. 3...

Hydroxypropyl methylcellulose (HPMC) is a polymer made of cellulose backbone with etherified methoxy and hydroxypropyl substitutions that undergoes reversible inverse thermo-gelation upon heating. The follows two-step mechanism: first, phase separation occurs, then fibrils, formed in the polymer-rich phase, entangle to form three-dimensional gel network. This work aims at understanding influenc...

This work is the continuation of a study focused on establishing relations between surface thermodynamic properties and in vitro release mechanisms using a model drug (ampicillin trihydrate), besides analyzing the granulometric properties of new polymeric materials and thus establishing the potential to be used in the pharmaceutical field as modified delivery excipients. To do this, we used cop...

Using time resolved ESR spectroscopy and photoflash conductivity the uncatalysed, first order decay of 2-hydroxy-propyl-2-peroxyl radicals and the uncatalysed, first order generation of 0 2~ and H + were measured to have the same rate constants. The formation of 0 2~ and H+ was measured in H20 and D 20 and a kinetic isotope effect of kH/k = D3.5 was obtained. Comparing the rate constants of the...

Three layered pellets of budesonide were prepared for colon delivery by the extrusion-spheronization method. The coatings consisted of hydroxypropylmethyl cellulose (HPMC) (as barrier layer), Eudragit E (as rate controlling layer) and hydroxypropylmethyl cellulose acetate succinate (HPMC AS) (as enteric layer). The rate controlling layer was further modified using various pore formers. Dissolut...

OBJECTIVE High-viscosity hydroxypropylmethylcellulose (HV-HPMC) is a modified cellulose fiber that produces a viscous gel in the gastrointestinal tract. Clinical trials demonstrate that consumption of HV-HPMC significantly lowers cholesterol, but limited information has been available on the influence of HV-HPMC on postprandial insulin and glucose responses. The objective of this investigation ...

The present investigation reports the design and evaluation of six-hour extended release film-coated matrix tablets of cephalexin using different grades of hydrophilic polymer hydroxypropylmethylcellulose (HPMC) employing direct compression method. The preformulation studies performed included the physical compatibility studies, Differential Scanning Calorimetry analysis, drug characterization ...