During the last few years it was observed that anhydrides of carboxylic and phosphoric acids appear as intermediates in metabolism. For one of these, acetyl phosphate, a method of determination had been worked out (I), based on a differential precipitation of calcium acetyl and inorganic phosphate with subsequent phosphate determination in the separate fractions. Such a procedure, founded on a ...

Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum. Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.

Described herein is a protocol for the metal-free, photo-induced borylation of unactivated C(sp 3 )–H bonds γ to an O -oxalate hydroxamic ester functionality.

The addition of an HDAC inhibitor, suberoylanilide hydroxamic acid (SBHA), to the culture medium of Cladosporium colocasiae, dramatically altered its metabolic profiles. Analysis of the culture broth extract led to the isolation of two new acetylenic sterols (1-2). The isolated compounds were further evaluated for their cytotoxic and antibacterial activities. Compound 1 showed activity against ...

A number of hydroxamic acid derivatives which inhibit human histone deacetylases were investigated for efficacy against cultured bloodstream form Trypanosoma brucei. Three out of the four classes tested displayed significant activity. The majority of compounds blocked parasite growth in the submicromolar range. The most potent was a member of the sulphonepiperazine series with an IC(50) of 34nM...

The synthesis of y-glutamylhydroxamic acid from glutamine and hydroxylamine is catalyzed by glutamine synthetase in the presence of adenosine diphosphate, inorganic phosphate, and magnesium ions (l), and also by other enzyme preparations (2,3) that do not exhibit a requirement for nucleotides or metal ions. The synthesis of y-glutamylhydroxamic acid from glutamic acid and hydroxylamine that is ...

We have fabricated field-effect transistors from carbon nanotubes using a novel selective placement scheme. We use carbon nanotubes that are covalently bound to molecules containing a hydroxamic acid functionality. The functionalized nanotubes bind strongly to basic metal oxide surfaces, but not to silicon dioxide. Upon annealing, the functionalization is removed, restoring the electronic prope...

Histone deacetylase inhibitors (HDACi) are increasingly used as therapeutic agents, but the mechanisms by which they alter cell behaviour remain unclear. Here we use microarray expression analysis to show that only a small proportion of genes (∼9%) have altered transcript levels after treating HL60 cells with different HDACi (valproic acid, Trichostatin A, suberoylanilide hydroxamic acid). Diff...

The synthesis of y-glutamylhydroxamic acid from glutamine and hydroxylamine is catalyzed by glutamine synthetase in the presence of adenosine diphosphate, inorganic phosphate, and magnesium ions (l), and also by other enzyme preparations (2,3) that do not exhibit a requirement for nucleotides or metal ions. The synthesis of y-glutamylhydroxamic acid from glutamic acid and hydroxylamine that is ...