For the polymeric carriers of solid dispersions, it is important that themselves dissolve quickly and maintain supersaturated state amorphous drugs during their dissolution period to improve bioavailability. Amphipathic 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers can be dissolved in water, owing extremely high hydrophilicity MPC units, are used as an ideal feeder for drug molecules ...

Multiblock copolymers with charged blocks are complex systems that show great potential for enhancing the structural control of block copolymers. A pentablock terpolymer PMMA-b-PDMAEMA-b-P2VP-b-PDMAEMA-b-PMMA is investigated. It contains two types midblocks, which weak cationic polyelectrolytes, namely poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) and poly(2-vinylpyridine) (P2VP). Further...

the amphiphilic graft copolymer using chitosan (cs) as hydrophilic segment and poly (l-lactic acid) (plla) as hydrophobic segment, was prepared through a protection-graft-de protection route. chitosan is a polysaccharide comprising of copolymers of glucosamine and n-acetyl glucosamine. chitosan is the deacetylated derivative of chitin, which is one of the most abundant natural polysaccharides c...

Unimolecular polymeric micelles have several features, such as thermodynamic stability, small particle size, biocompatibility, and the ability to internalize hydrophobic molecules. These micelles have recently attracted significant attention in various applications, such as nano-reactors, catalysis, and drug delivery. However, few attempts have explored the formation mechanisms and conditions o...

A bead-and-spring model has been used to simulate the behavior of thermoresponsive asymmetric diblock amphiphilic copolymers with aid of Monte Carlo simulations. The alteration of the thermodynamic conditions was mimicked by using a Lennard-Jones potential, which was related to the measured temperatures by comparison with experimental data for aqueous solutions of two sets of diblock copolymers...

Block copolymers combining peptide and saccharide moieties may play a significant role in future applications of polymers in biology, as they can be viewed as simplified synthetic analogues of glycosylated proteins, which display a wide range of biological functions in nature. While a small number of oligosaccharides containing synthetic polypeptides have been described so far, here we present ...

We have newly constructed “multi-particle layered organization” of aromatic polyamide (poly-(Nalkylated benzamide), abbrev. PABAn, n : carbon number of side-chains) derivatives having both a rigid main chain and a flexible side chains by a Langmuir-Blodgett (LB) technique. This organization is composed of the build-up particle layers with highly regular arrangement along the c-axis. The particl...

Magnetite (Fe(3)O(4)) - loaded polymer micelles (denoted as "magnetomicelles") are produced by self-assembly of fluorine-containing amphiphilic poly(HFMA-g-PEGMA) copolymers with oleic acid modified Fe(3)O(4) nanoparticles in an aqueous medium. The oleic acid modified Fe(3)O(4) nanoparticles form small clusters in the poly(HFMA-g-PEGMA) micelles with a mean diameter of 100 nm and the magnetomic...