Polymer-layered silicate nanocomposites have generated great interest due to their improved thermal, mechanical and gas barrier properties compared to conventional composites or neat polymers. Since the surface of most polymers is usually hydrophobic and layered silicate nanoparticles are completely hydrophilic, interactions between them are not favourable. Thus, the first step in the direction...

The aim of this work was to develop cefdinir solid dispersions (CSDs) prepared using hydrophilic polymers with enhanced dissolution/solubility and in vivo oral bioavailability. CSDs were prepared with hydrophilic polymers such as hydroxypropyl-methylcellulose (HPMC; CSD1), carboxymethylcellulose-Na (CMC-Na; CSD2), polyvinyl pyrrolidone K30 (PVP K30; CSD3) at the weight ratio of 1:1 (drug:polyme...

The interaction of drugs and polymers used to incorporate in or surface modify/coat the liposomes can affect the phase transition, fluidity and other physical properties as well as in vivo fate of vesicles. In this study, differential scanning calorimetry (DSC) was used to investigate changes in the temperature and the enthalpy of phase transition of liposomes of various electrical charges foll...

Transdermal delivery of ondansetron hydrochloride is one of the promising ways to maximize the therapy in contrast to oral delivery. Current investigation efforts are focused in formulating the ondansetron hydrochloride matrix-type transdermal film by incorporating hydrophilic and hydrophobic polymers. In this study, ondansetron hydrochloride transdermal films were prepared using solvent evapor...

The development of new adhesive wound care products intended for an application over a prolonged time requires good water transporting properties of the adhesive for the maintenance of a suitable environment around the wound. The ability of polydimethylsiloxane (PDMS)-based silicone films to transport water has led to its use in skin pressure-sensitive adhesives and it would be advantageous to ...

Zwitterionic polymers have unique features, such as good compatibility, and show promise in the application of drug delivery. In this study, the zwitterionic copolymers, poly(ε-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine) with disulfide (PCL-ss-PMPC) or poly(ε-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine) or without disulfide (PCL-PMPC) and with different bloc...

Crystallization of metformin hydrochloride by solvent evaporation method was carried out in the presence of hydrophilic and hydrophobic polymers to investigate the influence of polymer in the agglomeration of the crystallites in–vitro. Transparent, prismatic shaped crystals (of size: 7 × 2 × 1.5 mm3) were crystallized in hydrophilic polymer hydroxypropyl methylcellulose (HPMC) and long rod shap...

We report the synthesis and self-assembly of amphiphilic, nonspherical, polymeric microparticles. Wedge-shaped particles bearing segregated hydrophilic and hydrophobic sections were synthesized in a microfludic channel by polymerizing across laminar coflowing streams of hydrophilic and hydrophobic polymers using continuous flow lithography (CFL). Particle monodispersity was characterized by mea...

Protein hydrophobic interaction has been considered the most important factor dominating protein folding, aggregation, gelling, self-assembly, adhesion, and cohesion properties. In this paper, morphology and phase separation of hydrophobic clusters, networks, and aggregates of soy globular protein polymers, induced by using a reducing agent (NaHSO3), are studied using microscopic instruments. T...

Hydrophobically modified alkali-soluble emulsion polymers (HASE) are a class of comblike associative polymers that can impart high viscosities to aqueous solutions. The rheology of HASE solutions can be tuned by the addition of surfactants, such as nonylphenol ethoxylates (NP e), where e is the length of the hydrophilic (ethoxylate) chain. While previous studies have considered individual surfa...