Objective: The main objective of the study is to formulate hydrophilic drug loaded sustained release nanoparticles with the size of 200 nm and to increase the encapsulation efficiency of the drug. Methodology: The nanoparticles were prepared by simple ionic gelation method using various concentrations of chitosan and TPP. The prepared nanoparticles were evaluated for particle size, shape, charg...

The purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. Polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) were evaluated for matrix-forming properties. A simplex lattice design was applied to systemically optimize the drug release profile. The amounts of PEO WSR 303, HPMC K15M and sodium bicarbonate were selected as independen...

The purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. Polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) were evaluated for matrix-forming properties. A simplex lattice design was applied to systemically optimize the drug release profile. The amounts of PEO WSR 303, HPMC K15M and sodium bicarbonate were selected as independen...

The Solid lipid nanoparticles (SLN) of hydrophilic dug isoniazid (INH), a first line antubericular drug are developed and the entrapment efficiency of drug in the SLN has been improved. The poor incorporation of watersoluble drugs is the problem associated with the incorporation of hydrophilic drugs in to SLN. The SLNs were prepared by ethanol injection method using tristearin and phospholipon ...

PURPOSE To evaluate a canine intestinal accessport model to study colonic absorption of drugs. The antiepileptic drugs phenytoin and gabapentin were chosen to study absorption of a lipophilic and hydrophilic compound, respectively. METHODS Drug plasma level-time plots were generated subsequent to small intestinal and colonic drug administration of both drugs. The poorly water-soluble phenytoi...

Swelling agents are hydrophilic crosslinked polymers, which swell from 10 to 1,000 times their own weight when placed in an aqueous medium. Depending on their swelling properties, these materials have been exploited in developing three different classes of materials in pharmaceutical industries, i.e. swellable matrices, superdisintegrants and swelling devices. Since their development, these pha...

The stochastic nature of single-molecule charge transport measurements requires collection of large data sets to capture the full complexity of a molecular system. Data analysis is then guided by certain expectations, for example, a plateau feature in the tunnelling current distance trace, and the molecular conductance extracted from suitable histogram analysis. However, differences in molecula...

Porous silicon (PSi) is an innovative inorganic material that has been recently developed for various drug delivery systems. For example, hydrophilic and hydrophobic PSi microparticles have been utilized to improve the dissolution rate of poorly soluble drugs and to sustain peptide delivery. Previously, the well-plate method has been demonstrated to be a suitable in vitro dissolution method for...

Oral instant membranes can be quickly wetted by the patient’s saliva and dissolved/disintegrated in mouth without need for drinking water chewing, exhibiting great promise patients from children to elderly who have difficulties with swallowing. However, reported oral load release only one single drug, which greatly hinders their potential applications. Herein, we employ a sequential electrospin...