BACKGROUND Ficus umbellata is a medicinal plant previously shown to endow estrogenic properties. Its major component was isolated and characterized as 7-methoxycoumarin (MC). Noteworthy, coumarins and the respective active metabolite 7-hydroxycoumarin analogs have shown aromatase inhibitory activity, which is of particular interest in the treatment of estrogen-dependent cancers. The present wor...

Despite the existence of important floristic and forest inventories in Paraná state, montane upper ecosystems still give rise to new species records plants. Here, we report for first time state Hydrocotyle itatiaiensis Brade (Araliaceae), a rare poorly studied endemic rainforests highland grasslands South Southeast regions Brazil. The previously known geographic distribution had 700 ...