Aldosterone receptor blockade and thiazide therapy effectively lower blood pressure in geriatric hypertension. Their impact on sympathetic nervous system function has not been evaluated. In a double-blind, randomized study, 36 patients with stage 1 hypertension underwent 6 months of therapy with either aldosterone receptor blockade (spironolactone, n=19; 68+/-1 years) or hydrochlorothiazide (n=...

Angiotensin receptor blockers (ARBs) are the first-line antihypertensive agents. In clinical practice, it is often difficult to achieve the recommended blood pressure level by ARBs in their ordinal dosages alone. This study examined the practical efficacy of a combination therapy of ARB with thiazide diuretics for lowering morning home blood pressure (MHBP) in comparison to high-dose ARB therap...

BACKGROUND Cardiac effects of hypertension include increased left ventricular (LV) mass and LV hypertrophy, as well as increased left atrial size, a predictor of stroke and atrial fibrillation. Although literature on reduction of LV mass with antihypertensive therapy is extensive, little information is available on effects of treatment on left atrial size. METHODS AND RESULTS Patients with mi...

Rapid, precise, accurate, and specific ratiospectra derivative spectrophotometry and a simple UV spectrophotometry using simultaneous equation methods are developed for the simultaneous determination of bisoprolol fumarate and hydrochlorothiazide from combined pharmaceutical dosage forms. For ratiospectra derivative spectrophotometry, the amplitudes were measured at 202.6 nm for bisoprolol fuma...

In man amiloride hydrochloride (MK-870) has been shown to be an orally effective diuretic which causes a positive potassium balance. It also enhances the saluretic effects of hydrochlorothiazide and ethacrynic acid and in addition prevents the negative potassium balance caused by these diuretics (Wilson et al., 1966; Gombos et al., 1966). Gombos et al. also studied its effects in 10 hypertensiv...