The mechanisms for the formation of N-substituted hydrazones by coupling alcohols and hydrazine, achieved sequential processes acceptorless dehydrogenation borrowing hydrogen, has been unveiled density functional theory (DFT) calculations. release water molecular hydrogen as subproducts, combined with Mn-PNN pincer based catalyst describe a green environment. Mechanistically, apart from describ...

Three bench-stable difluoromethylene phosphonate hydrazones were prepared from simple diethyl(difluoromethyl)phosphonate within two steps in good yields. The [3 + 2] cycloaddition reaction of these diazo precursors with aryl diazonium salts has been accomplished under metal-free conditions exclusive regioselectivity. This transformation provides practical access to a broad panel 2-aryl-2 H -tet...

The MDR-involved human GSTA1-1, an important isoenzyme overexpressed in several tumors leading to chemotherapeutic-resistant tumour cells, has been targeted by 2,2'-dihydroxybenzophenones and some of their carbonyl N-analogues, as its potential inhibitors. A structure-based library of the latter was built-up by a nucleophilic cleavage of suitably substituted xanthones to 2,2'-dihydroxy-benzophe...

Bis(p-tolyl) ketone p-tosylhydrazone (2) crystallized as three conformational polymorphs, forms 1-3, under different conditions. The crystal structure of form 1 has an N-H‚‚‚OdS dimer synthon, but forms 2 and 3 have no strong hydrogen bonds even though the molecule contains an SO2NH group. Polymorphs 1 and 3 are assigned as kinetic and thermodynamic forms on the basis of the criteria of lower e...

In Paper I of this series (1) a method was described for the paper chromatographic analysis of certain ketonic steroids as hydrazones formed with Girard’s Reagent T. When that technique was applied to the adrenal cortical hormones, however, certain deficiencies appeared. (a) The RI values of the individual steroid-Reagent T hydrazones were not sufficiently different to permit identification. (b...

Hydrazones derivatives of carbonyl compounds constitute an important class of biologically active compounds. Metal complexes of Schiff bases represent an important class of coordination compounds. Schiffs base containing hetero donar atom continue to provide the interesting facts in the fields of coordination chemistry. Literature studies on hydrazones have shown that these derivatives possess ...

The binding of appropriate metal ions to linear ligand strands obtained by hydrazone polycondensations generates channel-like complexes by reversible coiling of the ligand, thus allowing the generation of ion-induced, acid-base neutralisation fueled, molecular nanomechanical contraction/extension motions of large amplitude.

The title hydrazone compound, C(14)H(10)ClFN(2)O, adopts an E configuration about the C=N double bond. The dihedral angle between the two substituted benzene rings is 11.6 (2)°. The F atom is disordered over two sites with occupancies of 0.488 (2) and 0.512 (2). In the crystal, mol-ecules are linked through inter-molecular N-H⋯O hydrogen bonds, forming chains along the a axis. C-H⋯F and C-H⋯O i...

1,2,4-Triazoles are important heterocyclic motifs that widely found in molecular architectures with medicinal and pharmaceutical properties. Considering the importance of these scaffolds, many works have been published over last few decades. This review provides a focus on synthetic approaches towards 1,2,4-triazole derivatives from common precursors such as amidines, imidates, amidrazones, ary...

Dehydro-L-ascorbic acid is usually found in plant tissues in low concentrations and is always associated with ascorbic acid in much higher concentrations. One of the most reliable and direct methods for its estimation is that originally proposed by Roe & Kuether (1943) which is based on the formation of a 2:4-dinitrophenylosazone. Many plant tissues, however, contain so little dehydro-L-ascorbi...