For the detection of Cd(II) in aquatic media, a novel dicyanomethylene dihydrofuran hydrazone(DCDHFH)-based colorimetric chemosensor was developed. DCDHFH prepared by an azo-coupling process involving diazonium chloride 2, 4-dichloroaniline and heterocyclic moiety bearing active methyl group. The chromophore showed strong solvatochromism depending on solvent polarity due to electronic delocaliz...

An efficient method for the Citric acid-catalyzed synthesis of hydrazones Schiff base using 2,4-dinirtophenyl hydrazine. We have synthesized a series of hydrazones using 2,4-dinirtophenyl hydrazine as a source of amine and substituted aromatic aldehydes and aromatic ketones as a carbonyl source. Synthesized compounds were characterized by FT-IR techniques. Synthesis of above hydrazones using ci...

P. Souza* 3, M. A. Mendiola3, A. Arquerob, V. Fernández3, E. Gutiérrez-Pueblac, C. Ruiz-Valeroc a Departamento de Quimica (C -V III), Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049-Madrid, Spain b Departamento A.T.S.I., Facultad de Informätica, Universidad Politecnica de Madrid, M ontegancedo s/n, 28660-Boadilla del Monte, Madrid, Spain c Instituto de Ciencias de Mater...

Recently, we have reported a series of isatin hydrazone, two them, namely, 3-((2,6-dichlorobenzylidene)hydrazono)indolin-2-one (1) and 3-((2-chloro-6-fluorobenzylidene)hydrazono)indolin-2-one (2) having potent cytotoxicity, showing cyclin-dependent kinases (CDK2) inhibitory activity bearing recommended drug likeness properties. Since both compounds (1 2) showed against CDK2, assumed it would al...

A new ligand, N-isonicotinoyl-N'-o-hydroxythiobenzhydrazide (H(2)Iotbh), forms complexes [Co(Iotbh)(H(2)O)(2)], [M(Iotbh)] [M Ni(II) Cu(II) and Zn(ll)] and [M(Iotbh-H)(H(2)O)(2)] [M Mn(III), Fe(III)], which were characterized by various physico-chemical techniques. DMSO solution of metal complexes was observed to inhibit the growth of tumor in vitro, whereas the ligand did not. In vivo administ...

The condensation of 5-alkoxycarbonyl-1H-pyrrolediones with cyclic ketazinones was systematically investigated. It was discovered that the regioselectivity of this reaction can be easily swapped between two alternative directions affording derivatives of partially hydrogenated indole or benzofurane. The control of this regioselectivity is efficiently governed by steric effects at the hydrazone m...

We describe a method that enables specific and efficient conjugation of hydrazide-moieties to an IgG targeting the tumor neovasculature. The resulting chemically defined, homogeneous hydrazone-linked IgG conjugates remain immunoreactive and have a half-life of approximately 18 hours at physiological pH and temperature suitable for localized delivery of toxic drugs.

In the title hydrazone compound, C(14)H(10)FN(3)O(3), the dihedral angle between the two substituted benzene rings is 13.7 (3)°. The mol-ecule exists in a trans configuration with respect to the central methyl-idene unit. In the crystal, mol-ecules are linked through inter-molecular N-H⋯O hydrogen bonds, forming chains along the a axis.