1. Background 2. Technical Limitations 3. OTEC and the Environment 4. Engineering Challenges 5. Open Cycle OTEC 6. The 210 kW OC-OTEC Experimental Apparatus 7. Design of a Small Land-Based OC-OTEC Plant 8. Closed Cycle OTEC 9. Design of a Pre-Commercial Floating Hybrid-OTEC Plant 10. Potential Sites 11. Economic Considerations and Market Potential 12. Hydrogen Production 13. Externalities Gloss...

Nowadays, computer architecture researches mainly focus on the multicore hardware and software design. As compared with the traditional uniprocessor counterpart, the system complexity of multicore simulators is dramatically augmented, which is spurred by the increase in core number. Full-system fidelity, fast simulation speed, and cycle-level accuracy are the essential requirements of the advan...

The timing of DNA synthesis, mitosis and cell division is regulated by a complex network of biochemical reactions that control the activities of a family of cyclin-dependent kinases. The temporal dynamics of this reaction network is typically modeled by nonlinear differential equations describing the rates of the component reactions. This approach provides exquisite details about molecular regu...

As in other eukaryotes, cell division in plants is highly conserved and regulated by cyclin-dependent kinases (CDKs) that are themselves predominantly regulated at the posttranscriptional level by their association with proteins such as cyclins. Although over the last years the knowledge of the plant cell cycle has considerably increased, little is known on the assembly and regulation of the di...

Matings between D. melanogaster females and males of sibling species in the D. melanogaster complex yield hybrid males that die prior to pupal differentiation. We have reexamined a previous report suggesting that the developmental defects in these lethal hybrid males reflect a failure in cell proliferation that may be the consequence of problems in mitotic chromosome condensation. We also obser...

Electron cryo tomography (cryoET) is an ideal technique to study virus-host interactions at molecular resolution. Imaging of biological specimens in a frozen-hydrated state assures a close to native environment. Various virus-host cell interactions have been analysed in this way, with the herpesvirus 'life' cycle being the most comprehensively studied. The data obtained were further integrated ...

We show how to automatically learn the class of Hybrid Automata called Cycle-Linear Hybrid Automata (CLHA) in order to model the behavior of excitable cells. Such cells, whose main purpose is to amplify and propagate an electrical signal known as the action potential (AP), serve as the “biologic transistors” of living organisms. The learning algorithm we propose comprises the following three ph...

Parameter optimization for Hybrid Electric Vehicles (HEVs) is very time consuming due to the necessity to evaluate a simulation model. This bottleneck is usually removed by using metamodels as surrogates for the simulation. We consider metamodels for longitudinal dynamics simulation, which simulate a vehicle following a given driving cycle. Typical “top-down” metamodels are parametrized by both...