background: dental pulp stem cells can be used in regenerative endodontic therapy. the aim of this study was to introduce an efficient method for dental pulp stem cells isolation. materials and methods: in this in-vitro study, 60 extracted human third molars were split and pulp tissue was extracted. dental pulp stem cells were isolated by the following three different methods: (1) digestion of ...

background : cancer stem cells are a subgroup of tumor cells that have the capability for self-renewal and differentiation and are characterized by multiple markers. several studies have been conducted to identify these cells in colorectal cancer, including stem cell marker cd24. this study has evaluatedtheassociation of cd24 expression with clinicopathologic features and survival in an immunoh...

background: mesenchymal stem cells (mscs) with their potential to differentiate into mesodermal and non-mesodermal lineages have several immunomodulatory characteris-tics. these properties make them promising tools in cell and gene therapy. objective: to evaluate the potential therapeutic applications of autologous msc in improving clinical manifestations of ms patients. methods: ten patients w...

stem cells are undifferentiated cells with the ability of proliferation, regeneration, conversion to differentiated cells and producing various tissues. stem cells are divided into two categories of embryonic and adult. in another categorization stem cells are divided to totipotent, multipotent and unipotent cells. so far usage of stem cells in treatment of various blood diseases has been studi...

low-intensity laser therapy (lilt) is defined to supply direct biostimulative light energy to the cells. while several studies have demonstrated that lilt has stimulating effects on bone cells and can accelerate the repair process of the bone, others reported delayed fracture healing or no effects after lilt. the aim of this article was to review the studies evaluating the biomodulation effects...

chronic myeloid leukemia (cml) is a myeloproliferative disease of the hematopoietic stem cells, characterized by the presence of the philadelphia (ph) chromosome. although imatinib inhibits the bcr-abl kinase activity, clinical experiences confirm that imatinib may not target cml stem cells in vivo. the identification of signaling pathways responsible for the self-renewal properties of leukemic...

helicobacter pylori was the main cause of gastric cancer (gc) in all over the world that results in intestinal- and diffuse-type carcinoma. infection by this bacterium remains chronic for a long time. in vitro studies have highlighted the role of stem cells in gc. h. pylori infection results in tissue injury and the adult/tissue stem cells subsequently start to replace the dead cells. the genet...

background: mesenchymal stem cells (mscs) are multipotent cells that can be collected from different sources. under specific conditions, mscs can be differentiated to tissue specific cells in vitro. human umbilical cord mesenchymal stem cells (hucmscs) can easily be harvested and cultured in in vitro conditions. production of germ cells from mesenchymal stem cells is a very interesting and prom...