نتایج جستجو برای: human leukocyte antigens

تعداد نتایج: 1737533  

Journal: :Human reproduction update 2006
Thomas Vauvert F Hviid

The non-classical human leukocyte antigen (HLA) class Ib genes, HLA-E, -G and -F, are located on chromosome 6 in the human major histocompatibility complex (MHC). HLA class Ib antigens resemble the HLA class Ia antigens in many ways, but several major differences have been described. This review will, in particular, discuss HLA-G and its role in human reproduction and in the human MHC. HLA-G se...

Journal: :The Journal of Experimental Medicine 2003
Makoto Murata Edus H. Warren Stanley R. Riddell

Minor histocompatibility antigens (minor H antigens) are targets of graft-versus-host disease and graft-versus-leukemia responses after allogeneic human leukocyte antigen identical hematopoietic stem cell transplantation. Only a few human minor H antigens have been molecularly characterized and in all cases, amino acid differences between homologous donor and recipient proteins due to nucleotid...

2009
Till Strowig Cagan Gurer Alexander Ploss Yi-Fang Liu Frida Arrey Junji Sashihara Gloria Koo Charles M. Rice James W. Young Amy Chadburn Jeffrey I. Cohen Christian Münz

Many pathogens that cause human disease infect only humans. To identify the mechanisms of immune protection against these pathogens and also to evaluate promising vaccine candidates, a small animal model would be desirable. We demonstrate that primary T cell responses in mice with reconstituted human immune system components control infection with the oncogenic and persistent Epstein-Barr virus...

Journal: :Archives of pathology & laboratory medicine 2007
Sang-Hyun Hwang Yong-Hak Sohn Heung-Bum Oh Chang Yun Hwang Soong-Hwan Lee Eun-Soon Shin Kwan Jeh Lee

CONTEXT Chronic hepatitis B infection is the leading cause of cirrhosis and hepatocellular carcinoma. Human leukocyte antigen may be involved in the chronicity of hepatitis B virus (HBV) infection. OBJECTIVE To analyze the association between HBV chronicity and human leukocyte antigen alleles and haplotypes of 636 organ donors and recipients. DESIGN Subjects were categorized into 2 groups a...

Journal: :Infection and immunity 1980
S E Starr B Dalton T Garrabrant K Paucker S A Plotkin

Lymphocyte blastogenesis and interferon production were measured in adult human leukocyte cultures stimulated with purified or crude cytomegalovirus antigens. Leukocytes from seropositive adults underwent blastogenesis when stimulated with purified or crude Towne strain antigen, whereas neither antigen stimulated blastogenesis in cultures from seronegative donors. The concentrations of antigens...

Journal: :Journal of Immunology 2023

Abstract Mouse NK cells recognize MHC-I antigens via stochastically expressed inhibitory Ly49 receptors. The loss of expression on tumor (“missing self”) abrogates signals, resulting in activation. We have identified an anti-mouse pan mAb (M1/42), which blocks Ly49-MHC-I interactions but not TCR-MHC-I interactions. Administration M1/42 vivo markedly activated IFNg-producing that further drove t...

Dehghan M, Farivar S

Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The Human Leucocyte Antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...

2011
Danilo Santana Alessio Franceschi Cármino Antonio de Souza Francisco José Penteado Aranha Daniela Maira Cardozo Ana Maria Sell Jeane Eliete Laguila Visentainer

Hematopoietic stem cell transplantation is the treatment of choice for many hematologic diseases, such as multiple myeloma, bone marrow aplasia and leukemia. Human leukocyte antigen (HLA) compatibility is an important tool to prevent post-transplant complications such as graft rejection and graft-versus-host disease, but the high rates of relapse limit the survival of transplant patients. Natur...

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