BACKGROUND Factor VII is essential for coagulation activation by the extrinsic pathway. Hemorrhages of the central nervous system in patients with congenital factor VII deficiency seem to have a higher incidence compared with other congenital coagulopathies. The purpose of this paper is to report two rare cases of subarachnoid hemorrhage and factor VII deficiency. CASE DESCRIPTION Two cases o...

Inherited Factor VII deficiency is an autosomal recessive coagulation disorder with broad range of bleeding manifestations. The association between and absolute level poor. Usually, the associated FVII levels less than 1% normal value. prolongation prothrombin time only activated partial thromboplastin time. Very few pregnant women have been reported so far in English literature. We, hereby, re...

Coagulation Factor VII from bovine plasma is a glycoprotein containing a single peptide chain. The NH2-terminal sequence of Ala-Asx-Gly-Phe-Leu- is homologous with the NH2 termini of prothrombin, Factor IX, and the light chain of Factor X. Factor Xa in the presence of calcium ions and phospholipid cleaves Factor VII at an Arg-Ile bond in the sequence Arg-Ile-Val-Gly-Gly-, producing a two-chain ...

The risks of transmitting viral infection by blood and plasma-derived products have long been known and still remain an area of concern. In this study, in the process of purifying human factor VII from prothrombin complex, SID treatment using tri-n-butyl phosphate and Tween 80 was employed and its capability and efficacy was studied. The results indicated that the process did not affect th...

A procedure was developed to concentrate and partially purify porcine factor VIll:C from plasma by using conventional precipitation and chromatographic techniques. Blood from heparinized animal(s) was collected in citrate. soybean trypsin inhibitor. #{128}-aminocaproic acid and benzamidine. After aluminum hydroxide adsorption. polyethylene glycol-6000 precipatation. QAE-cellulose chromatography...

Clotting Factor VII activity emerges as a highly significant predictive factor for development of cardiovascular disease (CVD) In prospective trials. We have previously shown that In hypertriglyceridemlc Individuals a fraction of their clotting Factor VII molecules is present in an activated state In phosphollpase C-sensitive complexes in plasma. These complexes may explain the increased Factor...

Clotting Factor VII activity emerges as a highly significant predictive factor for development of cardiovascular disease (CVD) in prospective trials. We have previously shown that in hypertriglyceridemic individuals a fraction of their clotting Factor VII molecules is present in an activated state in phospholipase C-sensitive complexes in plasma. These complexes may explain the increased Factor...

Mucopolysaccharidosis VII (MPS VII) is a lysosomal storage disorder characterized by a deficiency in beta-glucuronidase activity, leading to systemic accumulation of poorly degraded glycosaminoglycans (GAG). Along with other morbidities, MPS VII is associated with pediatric spinal deformity. The objective of this study was to examine potential associations between abnormal lumbar spine matrix s...

Although small deletions, splice site abnormalities, missense, and nonsense mutations have been identified in patients with factor VII deficiency, there have been no reports of mutations in the factor VII promoter. We investigated a girl with factor VII levels that were less than 1% of normal in association with a severe bleeding diathesis. The patient is homozygous for a T to G transversion th...