نتایج جستجو برای: human adipocyte
تعداد نتایج: 1648450 فیلتر نتایج به سال:
Adipose tissue expansion in obesity involves a series of cycles of adipocyte hyperplasia, hypertrophy and hypoplasia due to alterations in adipogenesis, adipocyte cellular metabolism and cell death, respectively. Increased frequency of these cycles may lead to deterioration of adipocyte function and viability, accelerated exhaustion of the adipocyte progenitor pool and extensive adipose tissue ...
Lean and adipose tissue growth are two of the most important targets for manipulation in commercial livestock. Adipose tissue growth occurs by both hyperplasia and hypertrophy. The processes involved in adipocyte hypertrophy are relatively well understood but much less is known about adipocyte hyperplasia. The mature adipocyte has little capacity for cell division and the hyperplastic capacity ...
human adipose tissue represents an abundant, practical and appealing source of donor tissue for autologous cell replacement. recent findings have shown that stem cells within the stromalvascular fraction of adipose tissue display a multilineage developmental potential. adipose tissue-derived stem cells can be differentiated towards adipogenic, osteogenic, chondrogenic,myogenic and neurogenic li...
Human bone marrow derived mesenchymal stem cells (HBMSCs) have the potential to differentiate into cells such as adipocyte, osteocyte, hepatocyte and endothelial cells. In this study, the differentiation of hBMSCs into endothelial like-cells was induced in presence of vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF-1). The differentiated endothelial cells were exam...
Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed in mammals. We discovered in the mouse that during wound healing, adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and nonadipogenic. Myofibroblast reprogramming required neogenic hair follicles, which triggered bone morphogene...
We have recently generated knockout mice for the Cbx7 gene, coding for a polycomb group protein that is downregulated in human malignant neoplasias. These mice develop liver and lung adenomas and carcinomas, which confirms a tumour suppressor role for CBX7. The CBX7 ability to downregulate CCNE1 expression likely accounts for the phenotype of the Cbx7-null mice. Unexpectedly, Cbx7-knockout mice...
Not least among the notably important advances in knowledge concerning the origin and development of white adipose tissue has been the recognition of the adipocyte precursor and the demonstration that such cells can be isolated from mature tissue and be induced to differentiate to adipocytes in vitro. The interest generated in the nature, origin, proliferation and differentiation of the adipocy...
human bone marrow derived mesenchymal stem cells (hbmscs) have the potential to differentiate into cells such as adipocyte, osteocyte, hepatocyte and endothelial cells. in this study, the differentiation of hbmscs into endothelial like-cells was induced in presence of vascular endothelial growth factor (vegf) and insulin-like growth factor (igf-1). the differentiated endothelial cells were exam...
Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway. This suggested to us an explanation for adipose tissue loss in partial lipodystrophy, a rare human condition usually associated with the immunoglobulin G(IgG) autoantibody ...
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