Using combinatorial methods, we synthesized a series of new vinyl amide monomers and graft-polymerized them to light-sensitive poly(ether sulfone) (PES) porous films for protein resistance. To increase the discovery rate and statistical confidence, we developed high throughput surface modification methods (HTP) that allow synthesis, screening and selection of desirable monomers from a large lib...

Interferon-alpha (IFN) is widely used in the treatment of certain cancers and viral infections, including hepatitis C (HCV). Unfortunately, depression is a common side effect of IFN therapy, affecting approximately a third of HCV patients receiving IFN therapy. Studies have shown that selective serotonin reuptake inhibitors (SSRIs) can effectively treat IFN-induced depression in only 63-75% of ...

Background: The serotonin precursor 5-hydroxy-L-[β-C]tryptophan ([C]HTP) is in clinical use for localization of neuroendocrine tumors and has been suggested as a proxy marker for pancreatic islet cells. However, degradation by monoamine oxidase-A (MAO-A) reduces retention and the contrast to non-endocrine tissue. Methods: A synthesis method was developed for 5-hydroxy-L-[β-CH]tryptophan ([C]DHT...

Unilateral cervical spinal cord hemisection (i.e., C2Hx) usually interrupts the bulbospinal respiratory pathways and results in respiratory impairment. It has been demonstrated that activation of the serotonin system can promote locomotor recovery after spinal cord injury. The present study was designed to investigate whether serotonergic activation can improve respiratory function during the c...

Results 13 Juvenile-SLE female patients were included, with disease onset between 6 and 16 years of age (mean 11,8 years), and mean disease duration of 6,6 years (2-15 years). One patient had moderate to severe aortic regurgitation (AoR), one had pulmonary hypertension (HTP), 5 patients had systemic hypertension (HTA); none smoked. The majority of patients presented at least one criteria of LV ...

Rats were pretreated with either carbidopa (25 mg/kg 30 min previously) or phenelzine (50 mg/kg 18 h and 12 mg/kg 90 min previously) before being given 5-HTP (150 or 350 mg/kg) or paroxetine (12 mg/kg). In carbidopa-treated animals, 5-HTP (150 mg/kg) evoked many wet-dog shakes (WDS) without changing receptor numbers, but an increase in the dose of 5-HTP to 350 mg/kg paradoxically increased the ...

Starting in 2003, Turkey introduced major health system reforms through the Health Transformation Program (HTP). The HTP aimed to address inequities care services across Turkey. This study explores whether regional disparities several indicators persist ten years after HTP. For this purpose, we use administrative records and individual-level data from only regionally representative survey, Life...

A novel high throughput method for synthesis and screening of customized protein-resistant surfaces was developed. This method is an inexpensive, fast, reproducible and scalable approach to synthesize and screen protein-resistant surfaces appropriate for a specific feed. The method is illustrated here by combining a high throughput platform (HTP) approach together with our patented photo-induce...

We present updated values for the Human Toxicity Potential (HTP) of 349 pollutants. The HTP is a characterization method used to weight emissions, such as those listed in life-cycle inventories and toxic release inventories. HTP is a screening-level risk indicator that accounts for both toxicity and the potential to result in exposure, but that does not account for regional differences or varia...

We have examined using microdialysis the effect of intracranial self-stimulation (ICSS) on the in vivo hydroxylation rate of tyrosine and tryptophan in the medial prefrontal cortex (mPFC), nucleus accumbens (NAC) and striatum (STR). A decarboxylase inhibitor NSD-1015 was included in the perfusate, which enabled the simultaneous measurement of 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytrypt...