INTRODUCTION ..................................................................................... 163 I. THE HISTORY OF HSR IN THE UNITED STATES ................................. 165 II. WHY CALIFORNIA IS IMPORTANT ..................................................... 167 III. OPPOSITION TO HSR IN CALIFORNIA .............................................. 169 A. State Legislative Opposition ......

The conventional method of assessing the platelet response to hypotonic stress (HSR) was adapted to allow microtitre plate technology to be used. After water is added to a platelet suspension two sequential readings are taken at 414 nM on a vertical microplate reader. The difference between the second (three minutes) and the first (one minute) was defined as the HSR. This method allowed the rel...

Topic modeling has been an increasingly mature method to bridge the semantic gap between the low-level features and high-level semantic information. However, with more and more high spatial resolution (HSR) images to deal with, conventional probabilistic topic model (PTM) usually presents the images with a dense semantic representation. This consumes more time and requires more storage space. I...

The increase of the spatial resolution of remote-sensing sensors helps to capture the abundant details related to the semantics of surface objects. However, it is difficult for the popular object-oriented classification approaches to acquire higher level semantics from the high spatial resolution remote-sensing (HSR-RS) images, which is often referred to as the “semantic gap.” Instead of design...

1. 4,6-Dibromo-3-hydroxycarbazole (DBHC) was synthesized as an analogue of bromoeudistomin D (BED), a powerful Ca2+ releaser, and its pharmacological properties were examined. 2. In Ca2+ electrode experiments, DBHC (100 microM) markedly inhibited Ca2+ release from the heavy fraction of sarcoplasmic reticulum (HSR) induced by caffeine (1 mM) and BED (10 microM). 3. DBHC (0.1 to 100 microM) inhib...

Urban land expansion (ULE) is a crucial factor for socioeconomic and environmentally sustainable development. However, nowadays, the unprecedented scale of high-speed railway (HSR) construction in China could exert an important influence on ULE. This manuscript first reveals mechanism HSR ULE then employs difference-in-difference (DID) models to investigate this effect based data 280 prefecture...

Stress-induced reproductive dysfunction is a relatively common cause of infertility in women. In response to everyday life stress, some individuals readily develop reproductive dysfunction (i.e., they are stress sensitive), whereas others are more stress resilient. Female cynomolgus monkeys, when exposed to mild combined psychosocial and metabolic stress (change in social environment + 20% redu...

The molecular chaperone Hsp90 requires the assistance of immunophilins, co-chaperones, and partner proteins for the conformational maturation of client proteins. Hsp90 inhibition represents a promising anticancer strategy due to the dependence of numerous oncogenic signaling pathways upon Hsp90 function. Historically, small molecules have been designed to inhibit ATPase activity at the Hsp90 N-...

A megacity is usually defined as a metropolitan area with a total population in excess of 10 million people. The number of megacities is increasing worldwide: in 1950 they were 4; in 1980 they were 28, in 2002 they were 39 and by 2015 they will be 59. In most agglomerations and megacities, urban planning and public infrastructure can guide the urban development in order to achieve a proper sust...