Although human epidermal growth factor receptor 2 (HER2) overexpression is implicated in tumor progression for a variety of cancer types, how it dysregulates signaling networks governing cell behavioral functions is poorly understood. To address this problem, we use quantitative mass spectrometry to analyze dynamic effects of HER2 overexpression on phosphotyrosine signaling in human mammary epi...

The hadron resonance gas (HRG) model is often believed to correctly describe the confined phase of QCD. This assumption basis many phenomenological works on QCD thermodynamics and analysis yields in relativistic heavy ion collisions. We use first principle lattice simulations calculate corrections ideal HRG model. Namely, we determine subleading fugacity expansion coefficients grand canonical f...

Integration of biomarkers into the majority of drug development programs has led to a need for robust measurements and assay validation techniques for analyses of biological samples. The importance of solid methodologies for biomarker assessment is heightened by the fact that new drugs frequently only offer modest benefit and that many potential biomarkers are continuous variables, the applicat...

We study the chiral condensate for 2 + 1 flavor QCD with physical quarks within a non-interacting Hadron Resonance Gas (HRG) model. By including latest information on mass variation of hadrons concerning light quark mass, from lattice and perturbation theory, we show that it is possible to quite accurately account crossover transition even conventional HRG have calculated pseudocritical tempera...

Histidine-rich glycoprotein (HRGP) is a human plasma and platelet protein of apparently diverse biological functions. In this study a new interaction for HRGP is described. HRGP specifically interacts with fibrinogen as demonstrated by two independent systems. Using an enzyme-linked immunosorbent assay it was demonstrated that HRGP bound to adsorbed fibrinogen in a concentration-dependent and s...

The discovery and analysis of network patterns are central to the scientific enterprise. In the present work, we developed and evaluated a new approach that learns the building blocks of graphs that can be used to understand and generate new realistic graphs. Our key insight is that a graph’s clique tree encodes robust and precise information. We show that a Hyperedge Replacement Grammar (HRG) ...

Despite the fact that the epidermal growth factor (EGF) family member ERBB3 (HER3) is deregulated in many cancers, the list of ERBB3-interacting partners remains limited. Here, we report that the Apaf-1-interacting protein (APIP) stimulates heregulin-β1 (HRG-β1)/ERBB3-driven cell proliferation and tumorigenesis. APIP levels are frequently increased in human gastric cancers and gastric cancer-de...

We study the dynamical fluctuations of various particle yield ratios at different incident energies. Assuming that the particle production yields in the hydronic final state are due to equilibrium chemical processes (γ = 1), the experimental results available so far are compared with the hadron resonance gas model (HRG) taking into account the limited momentum acceptance in heavy-ion collisions...